有机氯农药与代谢功能障碍相关的脂肪变性肝病的关系：来自东风-同济队列的研究结果

IF 9.7 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-05-30 DOI:10.1016/j.envint.2025.109571

Yi Guo, Xin Guan, Yutong You, Chengyong Jia, Yuhui Lin, Zhen Yin, Yu Yin, Guorong Zhong, Yuying Wen, Wenhui Li, Hui Zhao, Shengli Chen, Xi Wang, Xinlian Li, Xuanwen Mu, Pinpin Long, Hao Wang, Xiaomin Zhang, Meian He, Yu Yuan, Tangchun Wu

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引用次数: 0

摘要

背景：代谢功能障碍相关脂肪变性肝病（MASLD）是全球最常见的慢性肝病。然而，其环境化学成分仍不清楚。目的探讨中国人群中有机氯农药（OCPs）与MASLD发病的关系。方法采用东风-同济队列，对1199人进行纵向研究。评估19例OCPs基线时的血清浓度，并使用更新后的指南定义MASLD。我们拟合多元逻辑回归模型来估计ocp与MASLD之间的关系。用限制三次样条曲线来说明它们潜在的非线性剂量-响应关系。我们还研究了β-HCH和ΣDDTs的相互作用和联合效应，并进行了分层分析以探索潜在的效应修饰。结果与最低四分位数相比，血清β-HCH和ΣDDTs最高四分位数的参与者MASLD的几率分别高出2.48倍和1.95倍[模型3:OR（95 %CI） = β-HCH 2.48 (1.37, 4.56)， ΣDDTs 1.95(1.20, 3.21)]。β-HCH与事件MASLD呈线性相关，但与ΣDDTs呈非线性关系（非线性P = 0.044）。分层分析表明，这种关联不能被人口统计学或生活方式因素显著改变。同时，高β-HCH和ΣDDTs的个体与低β-HCH的个体相比，MASLD的发生率最高[OR（95 % CI） = 2.90(1.66,5.18)]。结论：本纵向研究显示，β-HCH和ΣDDTs水平升高与MASLD发生率增加相关，并具有正联合效应。需要进一步关注OCP共暴露的有害影响和OCP的加速去除。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Association between organochlorine pesticides and metabolic dysfunction-associated steatotic liver disease: Findings from the Dongfeng-Tongji cohort

查看原文本刊更多论文

Association between organochlorine pesticides and metabolic dysfunction-associated steatotic liver disease: Findings from the Dongfeng-Tongji cohort

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally. However, its environmental chemical contributors remain unclear.

Objective

To estimate the association between organochlorine pesticides (OCPs) and incident MASLD among Chinese population.

Methods

We conducted a longitudinal study involving 1199 participants based on Dongfeng-Tongji cohort. Serum concentrations of 19 OCPs at baseline were assessed and MASLD was defined using the updated guidelines. We fitted multivariate logistic regression models to estimate the association between OCPs and MASLD. Restricted cubic spline was utilized to illustrate their potential non-linear dose-response relationships. We additionally investigated the interactive and joint effects of β-HCH and ΣDDTs, and performed stratified analyses to explore potential effect modifications.

Results

Compared to the lowest quartile, participants in the highest quartile of serum β-HCH and ΣDDTs had 2.48- and 1.95-fold higher odds of MASLD, respectively [Model 3: OR (95% CI) = 2.48 (1.37, 4.56) for β-HCH and 1.95 (1.20, 3.21) for ΣDDTs]. While β-HCH showed a linear association with incident MASLD, a non-linear relationship was noted for ΣDDTs (P for non-linear = 0.044). Stratified analysis suggested that the association could not be significantly modified by demographic or lifestyle factors. Meanwhile, individuals with both high β-HCH and ΣDDTs had the highest odds of MASLD compared to those with both low levels [OR (95% CI) = 2.90 (1.66, 5.18)].

Conclusions

This longitudinal study revealed that higher levels of β-HCH and ΣDDTs were associated with increased odds of MASLD, with a positive joint effect. More attention is needed on the harmful effects of OCP co-exposure and acceleration of OCP removal.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.