综合多组学揭示了特应性皮炎的长双歧杆菌菌株的不同宿主串扰。

IF 9.2 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Hoon Je Seong, Yoon Mee Park, Bong-Soo Kim, Hyun Ju Yoo, Taeyune Kim, Sun Mi Yoon, Jeong-Hyun Kim, So-Yeon Lee, Yun Kyung Lee, Dong-Woo Lee, Myung Hee Nam, Soo-Jong Hong
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引用次数: 0

摘要

婴儿肠道微生物群对长期健康至关重要,并与特应性皮炎(AD)有关,尽管其潜在机制尚不完全清楚。本研究使用多组学方法,包括宏基因组学、宿主转录组学和代谢组学分析,研究了31名AD婴儿和29名健康对照者的肠道微生物组与宿主的相互作用。AD患者的微生物多样性显著改变,长双歧杆菌和无芽梭菌与这些变化有关。在菌株水平上,只有长芽孢杆菌在组间存在显著差异,全基因组分析确定了可能影响氨基酸和脂质代谢产物的遗传变异。值得注意的是,在健康对照中更为普遍的长芽孢杆菌亚枝I与宿主转录组通路相关,这些转录组通路涉及磷脂酰肌醇3-激酶- akt信号通路和神经活性配体受体通路,以及特定代谢物,包括四氢皮质醇和鸟氨酸。这些发现强调了长芽孢杆菌菌株水平变化在婴儿中的作用,为与AD相关的微生物-宿主相互作用提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integrated multi-omics reveals different host crosstalk of atopic dermatitis-enriched Bifidobacterium longum Strains.

The infant gut microbiome is essential for long-term health and is linked to atopic dermatitis (AD), although the underlying mechanisms are not fully understood. This study investigated gut microbiome-host interactions in 31 infants with AD and 29 healthy controls using multi-omics approaches, including metagenomic, host transcriptomic, and metabolomic analyses. Microbial diversity was significantly altered in AD, with Bifidobacterium longum and Clostridium innocuum associated with these changes. At the strain-level, only B. longum differed significantly between groups, with pangenome analyses identifying genetic variations potentially affecting amino acid and lipid metabolites. Notably, B. longum subclade I, which was more prevalent in healthy controls, correlated with host transcriptomic pathways involved in phosphatidylinositol 3-kinase-AKT signaling and neuroactive ligand-receptor pathways, as well as specific metabolites, including tetrahydrocortisol and ornithine. These findings highlight the role of B. longum strain-level variation in infants, offering new insights into microbiome-host interactions related to AD.

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来源期刊
npj Biofilms and Microbiomes
npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology
CiteScore
12.10
自引率
3.30%
发文量
91
审稿时长
9 weeks
期刊介绍: npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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