{"title":"视频头脉冲试验和前庭诱发肌生成电位对顺铂放化疗期间前庭功能的定量评估。","authors":"Natsuki Takada, Hiroshi Okuda, Hirofumi Shibata, Natsuko Obara, Kenichi Mori, Kosuke Terazawa, Ryo Kawaura, Ryota Iinuma, Rina Kato, Tatsuhiko Yamada, Takuro Tsunoki, Chiyoko Makita, Takayuki Mori, Takenori Ogawa","doi":"10.1111/coa.14335","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>This study aimed to determine the effects of cisplatin on vestibular function.</p>\n </section>\n \n <section>\n \n <h3> Study Design</h3>\n \n <p>Prospective cohort study.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We measured vestibulo-ocular reflex gain (VOR gain), cervical vestibular-evoked myogenic potential amplitude (cVEMP amplitude) and hearing acuity before and after treatment in 28 patients treated with cisplatin-based chemoradiation to determine changes in hearing and vestibular function.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>VOR gain did not decrease significantly before and after treatment, but cVEMP amplitude decreased significantly (<i>p</i> < 0.01). Air and bone hearing level worsened significantly (<i>p</i> < 0.01). The VOR gain in the group receiving more than 200 mg/m<sup>2</sup> of cisplatin was significantly decreased compared with the group receiving less than 200 mg/m<sup>2</sup> (<i>p</i> < 0.05). The cVEMP amplitude and hearing level were not significantly different between the two groups. Even after adjusting for age and inner ear radiation dose, VOR gain was inversely related to increasing cisplatin dose (<i>β</i> = 0.19; SE = 0.08).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Patients treated with cisplatin-based chemoradiotherapy exhibited decreased VOR gain. Patients should undergo vestibular and auditory testing before and after chemoradiation to detect potential vestibular impairment earlier, and prompt initiation of vestibular physical therapy would increase patients' quality of life.</p>\n </section>\n </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 5","pages":"883-889"},"PeriodicalIF":1.5000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Quantitative Assessment of Vestibular Function by Video Head Impulse Test and Vestibular-Evoked Myogenic Potential During Cisplatin-Based Chemoradiation\",\"authors\":\"Natsuki Takada, Hiroshi Okuda, Hirofumi Shibata, Natsuko Obara, Kenichi Mori, Kosuke Terazawa, Ryo Kawaura, Ryota Iinuma, Rina Kato, Tatsuhiko Yamada, Takuro Tsunoki, Chiyoko Makita, Takayuki Mori, Takenori Ogawa\",\"doi\":\"10.1111/coa.14335\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>This study aimed to determine the effects of cisplatin on vestibular function.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Study Design</h3>\\n \\n <p>Prospective cohort study.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We measured vestibulo-ocular reflex gain (VOR gain), cervical vestibular-evoked myogenic potential amplitude (cVEMP amplitude) and hearing acuity before and after treatment in 28 patients treated with cisplatin-based chemoradiation to determine changes in hearing and vestibular function.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>VOR gain did not decrease significantly before and after treatment, but cVEMP amplitude decreased significantly (<i>p</i> < 0.01). Air and bone hearing level worsened significantly (<i>p</i> < 0.01). The VOR gain in the group receiving more than 200 mg/m<sup>2</sup> of cisplatin was significantly decreased compared with the group receiving less than 200 mg/m<sup>2</sup> (<i>p</i> < 0.05). The cVEMP amplitude and hearing level were not significantly different between the two groups. Even after adjusting for age and inner ear radiation dose, VOR gain was inversely related to increasing cisplatin dose (<i>β</i> = 0.19; SE = 0.08).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Patients treated with cisplatin-based chemoradiotherapy exhibited decreased VOR gain. Patients should undergo vestibular and auditory testing before and after chemoradiation to detect potential vestibular impairment earlier, and prompt initiation of vestibular physical therapy would increase patients' quality of life.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10431,\"journal\":{\"name\":\"Clinical Otolaryngology\",\"volume\":\"50 5\",\"pages\":\"883-889\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-05-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Otolaryngology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/coa.14335\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Otolaryngology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/coa.14335","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Quantitative Assessment of Vestibular Function by Video Head Impulse Test and Vestibular-Evoked Myogenic Potential During Cisplatin-Based Chemoradiation
Introduction
This study aimed to determine the effects of cisplatin on vestibular function.
Study Design
Prospective cohort study.
Methods
We measured vestibulo-ocular reflex gain (VOR gain), cervical vestibular-evoked myogenic potential amplitude (cVEMP amplitude) and hearing acuity before and after treatment in 28 patients treated with cisplatin-based chemoradiation to determine changes in hearing and vestibular function.
Results
VOR gain did not decrease significantly before and after treatment, but cVEMP amplitude decreased significantly (p < 0.01). Air and bone hearing level worsened significantly (p < 0.01). The VOR gain in the group receiving more than 200 mg/m2 of cisplatin was significantly decreased compared with the group receiving less than 200 mg/m2 (p < 0.05). The cVEMP amplitude and hearing level were not significantly different between the two groups. Even after adjusting for age and inner ear radiation dose, VOR gain was inversely related to increasing cisplatin dose (β = 0.19; SE = 0.08).
Conclusions
Patients treated with cisplatin-based chemoradiotherapy exhibited decreased VOR gain. Patients should undergo vestibular and auditory testing before and after chemoradiation to detect potential vestibular impairment earlier, and prompt initiation of vestibular physical therapy would increase patients' quality of life.
期刊介绍：
Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with:
current otorhinolaryngological practice
audiology, otology, balance, rhinology, larynx, voice and paediatric ORL
head and neck oncology
head and neck plastic and reconstructive surgery
continuing medical education and ORL training
The emphasis is on high quality new work in the clinical field and on fresh, original research.
Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject.
• Negative/null results
In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
