非妊娠期卵巢绒毛膜癌的临床与影像学特征1例。

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Xiaofeng Fu, Wei Chen, Jiang Zhu
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引用次数: 0

摘要

背景:非妊娠期卵巢绒毛膜癌(NGOC)是一种极为罕见的高度恶性卵巢生殖细胞肿瘤,临床表现无特异性,早期诊断具有挑战性。目前,关于NGOC的临床和影像学特征的详细报道很少。本病例报告讨论了一个罕见的青春期前青少年NGOC病例,并辅以文献综述,以提高临床医生对其表现、诊断和治疗的理解。病例介绍:一名10岁女性,无月经或性行为史,表现为持续下腹疼痛和阴道出血。术前影像学显示一个大的盆腔肿块,回声不均匀,血管丰富。血清人绒毛膜促性腺激素(hCG)水平明显升高(约297,000 IU/L)。术前影像学检查:超声和CT显示一个大的、不均匀的、血管增生的附件肿块,伴有坏死和囊性改变,提示恶性肿瘤。手术和病理结果:肿块起源于右附件,经剖腹手术切除。组织病理学证实NGOC,免疫组织化学支持,CD146、CK18、HCG和HPL等标记物呈强阳性,Ki-67指数高(>90%)。结论:在没有性生活的年轻女性中,HCG水平明显升高和影像学发现的巨大异质附件肿块应引起对NGOC的怀疑。早期识别和多模式诊断方法,包括影像学、生化和病理评估,对于及时干预、降低转移风险和改善预后至关重要。本报告有助于对NGOC的理解,并强调准确诊断对改善患者预后的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical and Imaging Characteristics of Non-Gestational Ovarian Choriocarcinoma: A Case Report.

Background: Non-gestational Ovarian Choriocarcinoma (NGOC) is an extremely rare and highly malignant ovarian germ cell tumor with nonspecific clinical manifestations, making early diagnosis challenging. At present, detailed reports on the clinical and imaging characteristics of NGOC are scarce. This case report discusses a rare instance of NGOC in a prepubertal adolescent, complemented by a literature review to enhance clinicians' understanding of its presentation, diagnosis, and treatment.

Case presentation: A 10-year-old female with no history of menstruation or sexual activity presented with persistent lower abdominal pain and vaginal bleeding. Preoperative imaging revealed a large pelvic mass with heterogeneous echogenicity and vascularity. Serum Human Chorionic Gonadotropin (hCG) levels were markedly elevated (>297,000 IU/L). Preoperative Imaging: Ultrasonography and CT demonstrated a large, heterogeneous, hypervascular adnexal mass with features of necrosis and cystic changes, suggesting malignancy. Surgical and Pathological Findings: The mass, originating from the right adnexa, was removed via laparotomy. Histopathology confirmed NGOC, supported by immunohistochemistry, showing strong positivity for markers like CD146, CK18, HCG, and HPL, along with a high Ki-67 index (>90%).

Conclusion: In young females with no sexual life, significantly elevated HCG levels and imaging findings of a large heterogeneous adnexal mass should raise suspicion for NGOC. Early recognition and multimodal diagnostic approaches, including imaging, biochemical, and pathological assessments, are essential for timely intervention, reducing metastatic risk and improving prognosis. This report contributes to the understanding of NGOC and emphasizes the importance of accurate diagnosis for better patient outcomes.

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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
246
审稿时长
1 months
期刊介绍: Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques. The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.
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