{"title":"乳制品来源的饱和脂肪与2型糖尿病和代谢综合征的风险无关：德黑兰脂质和葡萄糖研究","authors":"Zahra Gaeini, Parvin Mirmiran, Sevda Alvirdizadeh, Fereidoun Azizi","doi":"10.1186/s13098-025-01751-3","DOIUrl":null,"url":null,"abstract":"<p><p>Emerging evidence indicates that the health effects of saturated fatty acids (SFA) may differ depending on the food source from which they are derived. We aimed to determine the association between dairy-derived SFA and the risk of type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS). This research was carried out in the Tehran Lipid and Glucose Study, a cohort study of 2256 T2DM-free adults and 1713 MetS-free adults. Adjusted hazard ratios and 95% confidence intervals of T2DM and MetS were calculated in tertile categories of dairy-derived SFA. The risk of T2DM and MetS was estimated through multivariable Cox regression to substitute dairy-derived SFA with other sources of SFA. Participants in the second tertile of dairy-derived SFA had a higher risk of T2DM (HR = 1.59, 95% CI = 1.14-2.21); however, the association did not remain significant in the third tertile (P for trend = 0.082). There were no associations between dairy-derived SFA and the risk of MetS. Substituting dairy-derived SFA for other dietary sources of SFA was not related to the risk of T2DM or MetS. The association between dairy-derived SFA and the risk of T2DM and MetS is still an ongoing research topic. When making dietary choices, it is advisable to consider an overall balanced diet and lifestyle factors.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"178"},"PeriodicalIF":3.4000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121133/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dairy-derived saturated fats were not associated with risk of type 2 diabetes mellitus and metabolic syndrome: Tehran Lipid and Glucose Study.\",\"authors\":\"Zahra Gaeini, Parvin Mirmiran, Sevda Alvirdizadeh, Fereidoun Azizi\",\"doi\":\"10.1186/s13098-025-01751-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Emerging evidence indicates that the health effects of saturated fatty acids (SFA) may differ depending on the food source from which they are derived. We aimed to determine the association between dairy-derived SFA and the risk of type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS). This research was carried out in the Tehran Lipid and Glucose Study, a cohort study of 2256 T2DM-free adults and 1713 MetS-free adults. Adjusted hazard ratios and 95% confidence intervals of T2DM and MetS were calculated in tertile categories of dairy-derived SFA. The risk of T2DM and MetS was estimated through multivariable Cox regression to substitute dairy-derived SFA with other sources of SFA. Participants in the second tertile of dairy-derived SFA had a higher risk of T2DM (HR = 1.59, 95% CI = 1.14-2.21); however, the association did not remain significant in the third tertile (P for trend = 0.082). There were no associations between dairy-derived SFA and the risk of MetS. Substituting dairy-derived SFA for other dietary sources of SFA was not related to the risk of T2DM or MetS. The association between dairy-derived SFA and the risk of T2DM and MetS is still an ongoing research topic. When making dietary choices, it is advisable to consider an overall balanced diet and lifestyle factors.</p>\",\"PeriodicalId\":11106,\"journal\":{\"name\":\"Diabetology & Metabolic Syndrome\",\"volume\":\"17 1\",\"pages\":\"178\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-05-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121133/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetology & Metabolic Syndrome\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s13098-025-01751-3\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetology & Metabolic Syndrome","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13098-025-01751-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
新出现的证据表明，饱和脂肪酸（SFA）对健康的影响可能因其来源的食物而异。我们的目的是确定乳制品来源的SFA与2型糖尿病（T2DM）和代谢综合征（MetS）风险之间的关系。这项研究是在德黑兰脂质和葡萄糖研究中进行的，该研究对2256名无t2dm的成年人和1713名无mets的成年人进行了队列研究。计算了T2DM和MetS的校正风险比和95%置信区间，并对乳制品来源的SFA进行分类。通过多变量Cox回归，用其他来源的SFA替代乳制品来源的SFA，估计T2DM和MetS的风险。第二组乳制品源性SFA的参与者患T2DM的风险较高（HR = 1.59, 95% CI = 1.14-2.21）；然而，在第三个五分位数中，这种关联并不显著（趋势P = 0.082）。乳制品衍生的SFA与met风险之间没有关联。用乳制品来源的SFA替代其他膳食来源的SFA与T2DM或MetS的风险无关。乳制品来源的SFA与T2DM和MetS风险之间的关系仍然是一个正在进行的研究课题。在进行饮食选择时，建议考虑整体均衡的饮食和生活方式因素。
Dairy-derived saturated fats were not associated with risk of type 2 diabetes mellitus and metabolic syndrome: Tehran Lipid and Glucose Study.
Emerging evidence indicates that the health effects of saturated fatty acids (SFA) may differ depending on the food source from which they are derived. We aimed to determine the association between dairy-derived SFA and the risk of type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS). This research was carried out in the Tehran Lipid and Glucose Study, a cohort study of 2256 T2DM-free adults and 1713 MetS-free adults. Adjusted hazard ratios and 95% confidence intervals of T2DM and MetS were calculated in tertile categories of dairy-derived SFA. The risk of T2DM and MetS was estimated through multivariable Cox regression to substitute dairy-derived SFA with other sources of SFA. Participants in the second tertile of dairy-derived SFA had a higher risk of T2DM (HR = 1.59, 95% CI = 1.14-2.21); however, the association did not remain significant in the third tertile (P for trend = 0.082). There were no associations between dairy-derived SFA and the risk of MetS. Substituting dairy-derived SFA for other dietary sources of SFA was not related to the risk of T2DM or MetS. The association between dairy-derived SFA and the risk of T2DM and MetS is still an ongoing research topic. When making dietary choices, it is advisable to consider an overall balanced diet and lifestyle factors.
期刊介绍：
Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome.
By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.
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