促炎饮食与抑郁和焦虑风险：一项基于饮食炎症指数的前瞻性研究

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-05-28 DOI:10.1016/j.jad.2025.119533

Chunyang Pang , Huan Yu , Jiali Xie , Yinuo Chen , Wen Cao , Xinyue Yu , Luyi Zhu , Junwei Zhang , Lingfei Gao , Yaojia Li , Lihuai Du , Binbin Deng , Ling Ji

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引用次数: 0

摘要

食物含有促炎和抗炎成分，这些成分可能会影响情绪。本研究旨在通过膳食炎症指数（DII）评估饮食炎症与焦虑和抑郁之间的关系。方法从英国生物银行24小时饮食回忆问卷中的29种食物中计算sdii。使用医院记录中的国际疾病分类代码确定抑郁和焦虑障碍，而使用患者健康问卷-9和广泛性焦虑障碍问卷-7评估抑郁和焦虑情绪。Cox比例风险模型用于评估基线饮食炎症与未来抑郁/焦虑障碍之间的关系。在189,835名参与者14.1年的中位随访中，抑郁症和焦虑症的发病率分别为每10万人年257.25例和272.10例。平均DII为- 0.435，范围为- 6.566 ~ 5.449。DII得分较高的个体抑郁情绪风险较高(OR [95% CI] = 1.137 [1.111,1.162], P <；0.001)、抑郁障碍(HR(95%置信区间)= 1.063 [1.046,1.082],P & lt;0.001)、焦虑情绪(或(95%置信区间)= 1.094 (1.079 - -1.108),P & lt;0.001)，焦虑障碍(HR [95% CI] = 1.023 [1.007,1.040], P <；0.001)，在调整了社会人口、生活方式和医疗状况因素后。结论：具有促炎特征的饮食（反映为较高的DII）与未来患抑郁症和焦虑症的风险增加密切相关。在DII的指导下，抗炎饮食可能提供一种有希望的预防这些心理健康问题的方法。

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Pro-inflammatory diet and the risk of depression and anxiety: A prospective study based on the dietary inflammatory index

Background

Foods contain pro-inflammatory and anti-inflammatory components that may influence mood. This study aims to investigate the association between dietary inflammation, assessed by the Dietary Inflammatory Index (DII), and anxiety and depression.

Methods

DII was calculated from 29 food items in a 24-h diet recall questionnaire from the UK Biobank. Depression and anxiety disorders were identified using International Classification of Diseases codes from hospital records, while depressive and anxious moods were assessed using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 questionnaires. Cox proportional hazards models were used to assess the association between baseline dietary inflammation and future depression/anxiety disorders.

Results

Over a median follow-up of 14.1 years among 189,835 participants, the incidence of depression and anxiety disorders was 257.25 and 272.10 per 100,000 person-years, respectively. The mean DII was −0.435, with a range from −6.566 to 5.449. Individuals with higher DII scores exhibited an elevated risk of depressive mood (OR [95 % CI] = 1.137 [1.111,1.162], P < 0.001), depression disorders (HR [95 % CI] = 1.063 [1.046,1.082], P < 0.001), anxiety mood (OR [95 % CI] = 1.094 [1.079–1.108], P < 0.001), and anxiety disorders (HR [95 % CI] = 1.023 [1.007,1.040], P < 0.001), after adjusting for sociodemographic, lifestyle, and medical condition factors.

Conclusions

Diets with pro-inflammatory traits, reflected by a higher DII, were strongly linked to an increased risk of developing depression and anxiety in the future. An anti-inflammatory diet, guided by the DII, may offer a promising protective approach against these mental health issues.

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.