核苷类似物停药对乙型肝炎病毒相关急慢性肝衰竭患者生存结局的影响

IF 6.7 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Alimentary Pharmacology & Therapeutics Pub Date : 2025-05-29 DOI:10.1111/apt.70213

Yanxue Lin, Xueping Yu, Huimin Lin, Jiajia Han, Yan Yan, Xiaoting Zhao, Yijie Lin, Zixuan Huang, Yinyin Zheng, Yahong Gao, Wenjin Yuan, Meifang Zhou, Jiming Zhang, Dawu Zeng

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引用次数: 0

摘要

核苷(t)类似物（NA）的停药是乙型肝炎病毒（HBV）感染复发或爆发的重要原因，可能引发HBV相关的急性慢性肝衰竭（HBV- aclf）。虽然NA停药和慢性乙型肝炎自发性严重急性加重（SAE）都是公认的HBV-ACLF触发因素，但关于其不同临床轨迹的比较证据仍然缺乏。这项多中心回顾性队列研究旨在确定与sae引起的病例相比，NA戒断是否能独立预测hbv相关ACLF的不良结局。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Effect of Nucleos(t)ide Analogues Withdrawal on Survival Outcomes in Patients With Hepatitis B Virus-Related Acute-on-Chronic Liver Failure

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Effect of Nucleos(t)ide Analogues Withdrawal on Survival Outcomes in Patients With Hepatitis B Virus-Related Acute-on-Chronic Liver Failure

Nucleos(t)ide analogues (NA) withdrawal is an important cause of hepatitis B virus (HBV) infection relapse or flare, potentially triggering HBV-related acute-on-chronic liver failure (HBV-ACLF). Although both NA withdrawal and spontaneous severe acute exacerbation (SAE) of chronic hepatitis B are recognised HBV-ACLF triggers, comparative evidence regarding their distinct clinical trajectories remains absent. This multicenter retrospective cohort study sought to determine whether NA withdrawal independently predicts adverse outcomes in HBV-related ACLF compared to SAE-induced cases.

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来源期刊

Alimentary Pharmacology & Therapeutics 医学-胃肠肝病学

CiteScore

15.60

自引率

7.90%

发文量

527

审稿时长

3-6 weeks

期刊介绍： Alimentary Pharmacology & Therapeutics is a global pharmacology journal focused on the impact of drugs on the human gastrointestinal and hepato-biliary systems. It covers a diverse range of topics, often with immediate clinical relevance to its readership.