来自母体NK细胞的颗粒酶B干扰胎儿大脑发育

IF 60.9 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2025-05-30 DOI:10.1038/s41577-025-01196-9

Lucy Bird

引用次数: 0

摘要

一项研究描述了母体免疫激活如何通过个体自然杀伤细胞释放颗粒酶B的机制导致后代神经发育缺陷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Granzyme B from maternal NK cells perturbs fetal brain development

A study describes how maternal immune activation can lead to neurodevelopmental deficits in offspring, through a mechanism involving granzyme B release by decidual natural killer cells.

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.