{"title":"用于拉曼光谱的可扩展微型片上傅里叶变换光谱仪","authors":"Sarp Kerman, Xiao Luo, Zuoqin Ding, Zhewei Zhang, Zhuo Deng, Xiaofei Qin, Yuran Xu, Shuhua Zhai, Chang Chen","doi":"10.1038/s41377-025-01861-7","DOIUrl":null,"url":null,"abstract":"<p>Miniaturized spectrometers for Raman spectroscopy have the potential to open up a new chapter in sensing. Raman spectroscopy is essential for material characterization and biomedical diagnostics, however, its weak signal and the need for sub-nanometer resolution pose challenges. Conventional spectrometers, with footprints proportional to optical throughput and resolution, are difficult to integrate into compact devices such as wearables. Waveguide-based Fourier Transform Spectrometers (FTS) enable compact spectrometers, and multi-aperture designs can achieve high throughput for applications such as Raman spectroscopy; however, experimental research in this domain remains limited. In this work, we present a multi-aperture SiN waveguide-based FTS overcoming these limitations and enabling Raman spectroscopy of isopropyl alcohol, glucose, Paracetamol, and Ibuprofen with enhanced throughput. Our spectrometer chip, fabricated on a 200 mm SiN wafer, with 160 edge-coupled waveguide apertures connected to an array of ultra-compact interferometers and a small footprint of just 1.6 mm × 3.2 mm, achieves a spectral range of 40 nm and a resolution of 0.5 nm. Experimental results demonstrate that the least absolute shrinkage and selection operator (LASSO) regression significantly enhances Raman spectrum reconstruction. Our work on waveguide-based spectrometry paves the way for integrating accurate and compact Raman sensors into consumer electronics and space exploration instruments.</p>","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"105 1","pages":""},"PeriodicalIF":23.4000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Scalable miniature on-chip Fourier transform spectrometer for Raman spectroscopy\",\"authors\":\"Sarp Kerman, Xiao Luo, Zuoqin Ding, Zhewei Zhang, Zhuo Deng, Xiaofei Qin, Yuran Xu, Shuhua Zhai, Chang Chen\",\"doi\":\"10.1038/s41377-025-01861-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Miniaturized spectrometers for Raman spectroscopy have the potential to open up a new chapter in sensing. Raman spectroscopy is essential for material characterization and biomedical diagnostics, however, its weak signal and the need for sub-nanometer resolution pose challenges. Conventional spectrometers, with footprints proportional to optical throughput and resolution, are difficult to integrate into compact devices such as wearables. Waveguide-based Fourier Transform Spectrometers (FTS) enable compact spectrometers, and multi-aperture designs can achieve high throughput for applications such as Raman spectroscopy; however, experimental research in this domain remains limited. In this work, we present a multi-aperture SiN waveguide-based FTS overcoming these limitations and enabling Raman spectroscopy of isopropyl alcohol, glucose, Paracetamol, and Ibuprofen with enhanced throughput. Our spectrometer chip, fabricated on a 200 mm SiN wafer, with 160 edge-coupled waveguide apertures connected to an array of ultra-compact interferometers and a small footprint of just 1.6 mm × 3.2 mm, achieves a spectral range of 40 nm and a resolution of 0.5 nm. Experimental results demonstrate that the least absolute shrinkage and selection operator (LASSO) regression significantly enhances Raman spectrum reconstruction. Our work on waveguide-based spectrometry paves the way for integrating accurate and compact Raman sensors into consumer electronics and space exploration instruments.</p>\",\"PeriodicalId\":18069,\"journal\":{\"name\":\"Light-Science & Applications\",\"volume\":\"105 1\",\"pages\":\"\"},\"PeriodicalIF\":23.4000,\"publicationDate\":\"2025-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Light-Science & Applications\",\"FirstCategoryId\":\"1089\",\"ListUrlMain\":\"https://doi.org/10.1038/s41377-025-01861-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPTICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Light-Science & Applications","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.1038/s41377-025-01861-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPTICS","Score":null,"Total":0}
引用次数: 0
摘要
小型化的拉曼光谱仪有可能在传感领域开辟新的篇章。拉曼光谱对于材料表征和生物医学诊断至关重要,但其微弱的信号和对亚纳米分辨率的需求带来了挑战。传统光谱仪的占用面积与光学吞吐量和分辨率成正比,很难集成到可穿戴设备等紧凑型设备中。基于波导的傅立叶变换光谱仪(FTS)实现了紧凑的光谱仪,多孔径设计可以实现高吞吐量的应用,如拉曼光谱;然而,这一领域的实验研究仍然有限。在这项工作中,我们提出了一种基于多孔径SiN波导的FTS,克服了这些限制,并使异丙醇、葡萄糖、扑热息痛和布洛芬的拉曼光谱具有更高的通量。我们的光谱仪芯片在200mm的SiN晶圆上制造,160个边缘耦合波导孔连接到超紧凑干涉仪阵列,占地面积仅为1.6 mm × 3.2 mm,光谱范围为40 nm,分辨率为0.5 nm。实验结果表明,最小绝对收缩和选择算子(LASSO)回归显著增强了拉曼光谱重建。我们在基于波导的光谱分析方面的工作为将精确和紧凑的拉曼传感器集成到消费电子产品和空间探索仪器中铺平了道路。
Scalable miniature on-chip Fourier transform spectrometer for Raman spectroscopy
Miniaturized spectrometers for Raman spectroscopy have the potential to open up a new chapter in sensing. Raman spectroscopy is essential for material characterization and biomedical diagnostics, however, its weak signal and the need for sub-nanometer resolution pose challenges. Conventional spectrometers, with footprints proportional to optical throughput and resolution, are difficult to integrate into compact devices such as wearables. Waveguide-based Fourier Transform Spectrometers (FTS) enable compact spectrometers, and multi-aperture designs can achieve high throughput for applications such as Raman spectroscopy; however, experimental research in this domain remains limited. In this work, we present a multi-aperture SiN waveguide-based FTS overcoming these limitations and enabling Raman spectroscopy of isopropyl alcohol, glucose, Paracetamol, and Ibuprofen with enhanced throughput. Our spectrometer chip, fabricated on a 200 mm SiN wafer, with 160 edge-coupled waveguide apertures connected to an array of ultra-compact interferometers and a small footprint of just 1.6 mm × 3.2 mm, achieves a spectral range of 40 nm and a resolution of 0.5 nm. Experimental results demonstrate that the least absolute shrinkage and selection operator (LASSO) regression significantly enhances Raman spectrum reconstruction. Our work on waveguide-based spectrometry paves the way for integrating accurate and compact Raman sensors into consumer electronics and space exploration instruments.