Faheem Arshad, M M Samim, Paras Rohidas Borse, Ravi G Shankar, R Bharath, B H Gagantej, Pooja Mailankody, Subasree Ramakrishnan, Sarada Subramanian, Suvarna Alladi
{"title":"南亚临床队列中基于液体的非淀粉样生物标志物对阿尔茨海默病和相关痴呆的诊断价值","authors":"Faheem Arshad, M M Samim, Paras Rohidas Borse, Ravi G Shankar, R Bharath, B H Gagantej, Pooja Mailankody, Subasree Ramakrishnan, Sarada Subramanian, Suvarna Alladi","doi":"10.1002/dad2.70129","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The rising dementia burden and limited knowledge of fluid biomarkers in South Asians highlights this study's aim on evaluating their utility for the diagnosis of Alzheimer's disease and related dementias (ADRD).</p><p><strong>Methods: </strong>Participants with ADRD were recruited from a cognitive disorders clinic in India. We performed cognitive assessments and severity evaluations using standard tests. Serum and cerebrospinal fluid (CSF) levels of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), total tau, and ubiquitin C-terminal hydrolase L1 (UCHL1) were quantified using a Simoa HD analyzer.</p><p><strong>Results: </strong>Among the 101 participants, serum GFAP and NfL levels were significantly greater in dementia participants (<i>n</i> = 70) than controls. Serum biomarkers significantly correlated with their corresponding CSF levels. Significant correlations were noted for serum and CSF GFAP and NfL in Alzheimer's disease (<i>ρ</i> = 0.492, 0.664) and between serum and CSF NfL in frontotemporal dementia (<i>ρ</i> = 0.727). Serum GFAP, NfL, and UCHL1 demonstrated high diagnostic accuracy (area under the curve = 0.765-0.806).</p><p><strong>Discussion: </strong>Our results emphasize the role of fluid biomarkers in diagnosing dementia in low-resource settings in South Asians.</p><p><strong>Highlights: </strong>Serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) levels were significantly greater in patients with dementia than in healthy controls.Significant correlation was observed between the serum and cerebrospinal fluid levels of GFAP, NfL, and total tau independent of the baseline demographics or co-morbidities, indicating their potential role in clinical practice.Serum biomarker levels were related to the severity of dementia.This is one of few studies on fluid-based biomarkers in diverse cohorts with Alzheimer's disease and related dementias in the South Asian cohort with limited resources.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70129"},"PeriodicalIF":4.0000,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117190/pdf/","citationCount":"0","resultStr":"{\"title\":\"Diagnostic value of fluid-based non-amyloid biomarkers for Alzheimer's disease and related dementias in a clinic-based cohort from South Asia.\",\"authors\":\"Faheem Arshad, M M Samim, Paras Rohidas Borse, Ravi G Shankar, R Bharath, B H Gagantej, Pooja Mailankody, Subasree Ramakrishnan, Sarada Subramanian, Suvarna Alladi\",\"doi\":\"10.1002/dad2.70129\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The rising dementia burden and limited knowledge of fluid biomarkers in South Asians highlights this study's aim on evaluating their utility for the diagnosis of Alzheimer's disease and related dementias (ADRD).</p><p><strong>Methods: </strong>Participants with ADRD were recruited from a cognitive disorders clinic in India. We performed cognitive assessments and severity evaluations using standard tests. Serum and cerebrospinal fluid (CSF) levels of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), total tau, and ubiquitin C-terminal hydrolase L1 (UCHL1) were quantified using a Simoa HD analyzer.</p><p><strong>Results: </strong>Among the 101 participants, serum GFAP and NfL levels were significantly greater in dementia participants (<i>n</i> = 70) than controls. Serum biomarkers significantly correlated with their corresponding CSF levels. Significant correlations were noted for serum and CSF GFAP and NfL in Alzheimer's disease (<i>ρ</i> = 0.492, 0.664) and between serum and CSF NfL in frontotemporal dementia (<i>ρ</i> = 0.727). Serum GFAP, NfL, and UCHL1 demonstrated high diagnostic accuracy (area under the curve = 0.765-0.806).</p><p><strong>Discussion: </strong>Our results emphasize the role of fluid biomarkers in diagnosing dementia in low-resource settings in South Asians.</p><p><strong>Highlights: </strong>Serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) levels were significantly greater in patients with dementia than in healthy controls.Significant correlation was observed between the serum and cerebrospinal fluid levels of GFAP, NfL, and total tau independent of the baseline demographics or co-morbidities, indicating their potential role in clinical practice.Serum biomarker levels were related to the severity of dementia.This is one of few studies on fluid-based biomarkers in diverse cohorts with Alzheimer's disease and related dementias in the South Asian cohort with limited resources.</p>\",\"PeriodicalId\":53226,\"journal\":{\"name\":\"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring\",\"volume\":\"17 2\",\"pages\":\"e70129\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117190/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/dad2.70129\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/dad2.70129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Diagnostic value of fluid-based non-amyloid biomarkers for Alzheimer's disease and related dementias in a clinic-based cohort from South Asia.
Introduction: The rising dementia burden and limited knowledge of fluid biomarkers in South Asians highlights this study's aim on evaluating their utility for the diagnosis of Alzheimer's disease and related dementias (ADRD).
Methods: Participants with ADRD were recruited from a cognitive disorders clinic in India. We performed cognitive assessments and severity evaluations using standard tests. Serum and cerebrospinal fluid (CSF) levels of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), total tau, and ubiquitin C-terminal hydrolase L1 (UCHL1) were quantified using a Simoa HD analyzer.
Results: Among the 101 participants, serum GFAP and NfL levels were significantly greater in dementia participants (n = 70) than controls. Serum biomarkers significantly correlated with their corresponding CSF levels. Significant correlations were noted for serum and CSF GFAP and NfL in Alzheimer's disease (ρ = 0.492, 0.664) and between serum and CSF NfL in frontotemporal dementia (ρ = 0.727). Serum GFAP, NfL, and UCHL1 demonstrated high diagnostic accuracy (area under the curve = 0.765-0.806).
Discussion: Our results emphasize the role of fluid biomarkers in diagnosing dementia in low-resource settings in South Asians.
Highlights: Serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) levels were significantly greater in patients with dementia than in healthy controls.Significant correlation was observed between the serum and cerebrospinal fluid levels of GFAP, NfL, and total tau independent of the baseline demographics or co-morbidities, indicating their potential role in clinical practice.Serum biomarker levels were related to the severity of dementia.This is one of few studies on fluid-based biomarkers in diverse cohorts with Alzheimer's disease and related dementias in the South Asian cohort with limited resources.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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