Hana Arghavani, Jean-François Bilodeau, Iwona Rudkowska
{"title":"乳制品摄入对循环脂肪酸的影响及其与血压的关系：一项随机交叉试验。","authors":"Hana Arghavani, Jean-François Bilodeau, Iwona Rudkowska","doi":"10.1016/j.numecd.2025.104112","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aims: </strong>This study aimed to investigate the effects of high and adequate dairy intake (>4, 2-3 serving/day, respectively) on circulating fatty acids (FAs) and their associations with blood pressure (BP).</p><p><strong>Methods and results: </strong>A randomized crossover clinical trial was conducted with 27 participants (8 women, 19 men) at the CHU de Québec-Université Laval Research Center. Participants were assigned to either a high-dairy (HD) or adequate-dairy (AD) diet for six weeks, followed by a six-week washout period before crossing over. Plasma phospholipid-bound FAs were analyzed using gas chromatography, and BP and arterial stiffness were measured at each visit. Partial correlation analyses, generalized linear mixed models and machine learning techniques were employed to analyze the data. Pentadecanoic acid (15:0) and heptadecanoic acid (17:0) were positively correlated with dairy intake and showed increases after the HD. Palmitic acid (16:0) and total saturated FAs were positively associated with systolic (SBP) and diastolic (DBP), while 17:0 was inversely associated with diastolic BP.</p><p><strong>Conclusions: </strong>HD was associated with increased 15:0 and 17:0. Notably, 17:0 had an inverse association with diastolic BP, while 16:0 was positively linked. These findings highlight the importance of dietary strategies that incorporate specific FAs to enhance cardiovascular health.</p><p><strong>Registration number: </strong>NCT02961179.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104112"},"PeriodicalIF":3.3000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of dairy intake on circulating fatty acids and associations with blood pressure: A randomized crossover trial.\",\"authors\":\"Hana Arghavani, Jean-François Bilodeau, Iwona Rudkowska\",\"doi\":\"10.1016/j.numecd.2025.104112\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and aims: </strong>This study aimed to investigate the effects of high and adequate dairy intake (>4, 2-3 serving/day, respectively) on circulating fatty acids (FAs) and their associations with blood pressure (BP).</p><p><strong>Methods and results: </strong>A randomized crossover clinical trial was conducted with 27 participants (8 women, 19 men) at the CHU de Québec-Université Laval Research Center. Participants were assigned to either a high-dairy (HD) or adequate-dairy (AD) diet for six weeks, followed by a six-week washout period before crossing over. Plasma phospholipid-bound FAs were analyzed using gas chromatography, and BP and arterial stiffness were measured at each visit. Partial correlation analyses, generalized linear mixed models and machine learning techniques were employed to analyze the data. Pentadecanoic acid (15:0) and heptadecanoic acid (17:0) were positively correlated with dairy intake and showed increases after the HD. Palmitic acid (16:0) and total saturated FAs were positively associated with systolic (SBP) and diastolic (DBP), while 17:0 was inversely associated with diastolic BP.</p><p><strong>Conclusions: </strong>HD was associated with increased 15:0 and 17:0. Notably, 17:0 had an inverse association with diastolic BP, while 16:0 was positively linked. 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Impact of dairy intake on circulating fatty acids and associations with blood pressure: A randomized crossover trial.
Background and aims: This study aimed to investigate the effects of high and adequate dairy intake (>4, 2-3 serving/day, respectively) on circulating fatty acids (FAs) and their associations with blood pressure (BP).
Methods and results: A randomized crossover clinical trial was conducted with 27 participants (8 women, 19 men) at the CHU de Québec-Université Laval Research Center. Participants were assigned to either a high-dairy (HD) or adequate-dairy (AD) diet for six weeks, followed by a six-week washout period before crossing over. Plasma phospholipid-bound FAs were analyzed using gas chromatography, and BP and arterial stiffness were measured at each visit. Partial correlation analyses, generalized linear mixed models and machine learning techniques were employed to analyze the data. Pentadecanoic acid (15:0) and heptadecanoic acid (17:0) were positively correlated with dairy intake and showed increases after the HD. Palmitic acid (16:0) and total saturated FAs were positively associated with systolic (SBP) and diastolic (DBP), while 17:0 was inversely associated with diastolic BP.
Conclusions: HD was associated with increased 15:0 and 17:0. Notably, 17:0 had an inverse association with diastolic BP, while 16:0 was positively linked. These findings highlight the importance of dietary strategies that incorporate specific FAs to enhance cardiovascular health.
期刊介绍：
Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.
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