肠道菌群在生活方式与血脂异常之间的中介作用和代谢途径。

IF 9.2 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Lijun Zeng, Bin Yu, Peibin Zeng, Zhuoma Duoji, Haojiang Zuo, Jian Lian, Tingting Yang, Yingxue Dai, Yuemei Feng, Peng Yu, Jiqi Yang, Shujuan Yang, Qingyu Dou
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引用次数: 0

摘要

肠道微生物特征是否在从生活方式到血脂异常的过程中起作用尚不清楚。在这项横断面研究中,我们对来自中国多民族队列的994名成年人进行了全宏基因组关联分析和粪便代谢组学分析。共有26种微生物被确定为生活方式因素与血脂异常风险之间的媒介。具体来说,瘤球菌的丰度介导了生活方式与血脂异常、低密度脂蛋白胆固醇升高、总胆固醇升高和甘油三酯升高风险之间的关联。在一个外部验证队列中,gnavus、Alistipes shahii和Lachnospira eligens被证实与血脂异常有关。潜在的代谢途径包括花生四烯酸、胆汁酸和芳香氨基酸代谢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia.

Whether the role of gut microbial features lies in the pathways from lifestyles to dyslipidemia remains unclear. In this cross-sectional study, we conducted a metagenome-wide association analysis and fecal metabolomic profiling in 994 adults from the China Multi-Ethnic cohort. A total of 26 microbial species were identified as mediators between lifestyle factors and risk for dyslipidemia. Specifically, the abundance of [Ruminococcus] gnavus mediated the associations between lifestyles and risks for dyslipidemia, elevated low-density lipoprotein cholesterol, elevated total cholesterol, and elevated triglycerides. [Ruminococcus] gnavus, Alistipes shahii, and Lachnospira eligens were replicated to be associated with dyslipidemia in an external validation cohort. The potential metabolic pathways included arachidonic acid, bile acid, and aromatic amino-acid metabolism.

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来源期刊
npj Biofilms and Microbiomes
npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology
CiteScore
12.10
自引率
3.30%
发文量
91
审稿时长
9 weeks
期刊介绍: npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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