一项双盲随机对照试验：一项舌阻力训练计划可提高患有轻度认知障碍的体弱老年人的力量、耐力和吞咽能力。

IF 5.3 2区医学 Q1 GERIATRICS & GERONTOLOGY

GeroScience Pub Date : 2025-05-29 DOI:10.1007/s11357-025-01715-5

Shu-Hua Kao, Ruey Chen, Pi-Yu Su, Kondwani Joseph Banda, Chien-Mei Sung, Chia-Hui Wang, Kai-Jo Chiang, Melati Fajarini, Kuei-Ru Chou

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引用次数: 0

摘要

背景：吞咽和舌头功能的年龄相关性下降与轻度认知障碍（MCI）和虚弱有关。然而，由于方法的变化和缺乏随访，关于舌阻力练习对MCI体弱老年人有效性的证据有限。目的：探讨舌阻力训练方案（TRTP）在改善体弱老年人MCI患者舌力（舌前力[ATS]和舌后力[PTS]）、舌耐力（舌前力[ATE]和舌后力[PTE]）和吞咽压力（唾液吞咽压力[SSP]和费力吞咽压力[ESP]）方面的效果。方法：前瞻性、双盲、随机对照试验设计。参与者被随机分配到TRTP组（n = 23）或鼓起脸颊组（n = 23）。采用涉及意向处理方法的广义估计方程模型进行数据分析。结果：共招募了46名患有轻度认知损伤的体弱老年人(女性：80.0%；平均年龄：75.7±6.7岁)。TRTP显著改善ATS (β = 6.4；p = 0.016, 95%CI = 1.2 ~ 11.5), SSP (β = 12.5；p 0.05)。结论：TRTP可有效改善老年弱MCI患者的ATS、SSP和ESP。未来的研究应结合渐进式阻力训练、持续等长和等速运动训练以及特定任务训练。临床试验注册：NCT06766487（2024.12.02）。

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A tongue resistance training program improves strength, endurance, and swallowing in frail older adults with mild cognitive impairment: a double-blind randomized controlled trial.

Background: Age-associated decline in swallowing and tongue function is associated with mild cognitive impairment (MCI) and frailty. However, evidence regarding effectiveness of tongue resistance exercises in frail older adults with MCI is limited with methodological variations and lack of follow-up.

Objective: To determine the effectiveness of a tongue resistance training program (TRTP) in improving tongue strength (anterior tongue strength [ATS] and posterior tongue strength [PTS]), tongue endurance (anterior tongue endurance [ATE] and posterior tongue endurance [PTE]), and swallowing pressure (saliva swallowing pressure [SSP] and effortful swallowing pressure [ESP]) in frail older adults with MCI.

Methods: A prospective, double-blind, randomized controlled trial design. Participants were randomly assigned to TRTP (n = 23) or cheek-bulging exercises (n = 23). Generalized estimating equation model involving intention-to-treat approach was used for data analysis.

Results: A total of 46 frail older adults with MCI were recruited (women: 80.0%; mean age: 75.7 ± 6.7 years). TRTP significantly improved ATS (β = 6.4; p = 0.016, 95%CI = 1.2-11.5), SSP (β = 12.5; p < 0.001, 95%CI = 9.2-15.9), and ESP (β = 14.2; p < 0.001, 95%CI = 9.3-19.0) at immediate posttest. However, no significant improvements were observed for PTS (β = 4.0; p = 0.231, 95%CI = - 2.6-10.6), ATE (β = - 4.5; p = 0.173, 95%CI = - 10.9-2.0), and PTE (β = 2.4; p = 0.489, 95%CI = - 4.5-9.4). At 12-week follow-up, sustained improvements were observed for SSP (β = 6.1; p < 0.001, 95%CI = 2.6-9.7) and ESP (β = 7.9; p < 0.001, 95%CI = 3.9-11.9). No significant short-term effects on ATS, PTS, ATE, and PTE (p > 0.05).

Conclusion: TRTP effectively improved ATS, SSP, and ESP in frail older adults with MCI. Future research should integrate progressive resistance exercises sustained isometric and isokinetic exercises, and task-specific training. Trial Registration Clincialtrials.gov: NCT06766487(2024.12.02).

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来源期刊

GeroScience Medicine-Complementary and Alternative Medicine

CiteScore

10.50

自引率

5.40%

发文量

182

期刊介绍： GeroScience is a bi-monthly, international, peer-reviewed journal that publishes articles related to research in the biology of aging and research on biomedical applications that impact aging. The scope of articles to be considered include evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, and psychology.