{"title":"中国中老年人群抑郁症状、身体功能和心血管疾病风险的相关性","authors":"Miao Li, Shuo Zhuang, Yan Gao","doi":"10.3389/fmed.2025.1513614","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Current research suggests that depressive symptoms and physical function increase the risk of developing cardiovascular disease (CVD), but how these factors interact to increase the risk of CVD remains unclear. Therefore, we used data from Chinese middle-aged and older adults to investigate the relationship between depressive symptoms and physical function and CVD risk.</p><p><strong>Methods: </strong>Using information from the China Health and Retirement Longitudinal Study (CHARLS), we examined the relationship between depressive symptoms, physical functioning, and CVD risk in middle-aged and older Chinese adults. The subsequent seven-year endeavor, which ran from 2011 to 2018, enrolled Chinese adults who were middle-aged and older (≥45 years). The exposures of interest were symptoms of depression and physical impairment. To measure depression symptoms, the Center for Epidemiological Studies Depression Scale (CESD-10) was used. The physical disability was ascertained using the physical mobility function. Its principal endpoint was the incidence of CVD. Cox proportional hazards regression methods has been applied to ascertain 95% of the hazard ratios (HRs) and confidence intervals (CIs). Cox multivariate regression and stratified interaction analysis analyses were employed to investigate the association between depressive symptoms, physical functioning, and CVD.</p><p><strong>Results: </strong>A total of 1980 people were included, of whom the mean age of the participants was 56.4 ± 7.7 years, of whom 1,013 (51.2%) were women. During the maximum follow-up period of 7 years, 303 (15.3%) suffered from cardiovascular disease, of whom 246 (12.4%) had heart disease and 72 (3.6%) suffered from stroke. Compared with those with NDS (no depressive symptoms) (CESD <10) and NPD (no physical dysfunction), those with both DS (depressive symptoms) (CESD ≥10) and PD (physical dysfunction) had the highest risk of overall CVD (adjusted hazard ratio [HR], 1.88; 95% CI 1.18 to 3), coronary heart disease (HR, 2.45; 95% CI 1.44 to 4.18) and stroke (HR, 0.45; 95% CI 0.15 to 1.31), which were most common in people aged 60 years or younger.</p><p><strong>Conclusion: </strong>This study found that older adults with DS and PD were strongly associated with an increased risk of CVD.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1513614"},"PeriodicalIF":3.1000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116637/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of depressive symptoms, physical function, and cardiovascular disease risk in middle-aged and elderly Chinese.\",\"authors\":\"Miao Li, Shuo Zhuang, Yan Gao\",\"doi\":\"10.3389/fmed.2025.1513614\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Current research suggests that depressive symptoms and physical function increase the risk of developing cardiovascular disease (CVD), but how these factors interact to increase the risk of CVD remains unclear. Therefore, we used data from Chinese middle-aged and older adults to investigate the relationship between depressive symptoms and physical function and CVD risk.</p><p><strong>Methods: </strong>Using information from the China Health and Retirement Longitudinal Study (CHARLS), we examined the relationship between depressive symptoms, physical functioning, and CVD risk in middle-aged and older Chinese adults. The subsequent seven-year endeavor, which ran from 2011 to 2018, enrolled Chinese adults who were middle-aged and older (≥45 years). The exposures of interest were symptoms of depression and physical impairment. To measure depression symptoms, the Center for Epidemiological Studies Depression Scale (CESD-10) was used. The physical disability was ascertained using the physical mobility function. Its principal endpoint was the incidence of CVD. Cox proportional hazards regression methods has been applied to ascertain 95% of the hazard ratios (HRs) and confidence intervals (CIs). Cox multivariate regression and stratified interaction analysis analyses were employed to investigate the association between depressive symptoms, physical functioning, and CVD.</p><p><strong>Results: </strong>A total of 1980 people were included, of whom the mean age of the participants was 56.4 ± 7.7 years, of whom 1,013 (51.2%) were women. During the maximum follow-up period of 7 years, 303 (15.3%) suffered from cardiovascular disease, of whom 246 (12.4%) had heart disease and 72 (3.6%) suffered from stroke. Compared with those with NDS (no depressive symptoms) (CESD <10) and NPD (no physical dysfunction), those with both DS (depressive symptoms) (CESD ≥10) and PD (physical dysfunction) had the highest risk of overall CVD (adjusted hazard ratio [HR], 1.88; 95% CI 1.18 to 3), coronary heart disease (HR, 2.45; 95% CI 1.44 to 4.18) and stroke (HR, 0.45; 95% CI 0.15 to 1.31), which were most common in people aged 60 years or younger.</p><p><strong>Conclusion: </strong>This study found that older adults with DS and PD were strongly associated with an increased risk of CVD.</p>\",\"PeriodicalId\":12488,\"journal\":{\"name\":\"Frontiers in Medicine\",\"volume\":\"12 \",\"pages\":\"1513614\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116637/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fmed.2025.1513614\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fmed.2025.1513614","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Association of depressive symptoms, physical function, and cardiovascular disease risk in middle-aged and elderly Chinese.
Objective: Current research suggests that depressive symptoms and physical function increase the risk of developing cardiovascular disease (CVD), but how these factors interact to increase the risk of CVD remains unclear. Therefore, we used data from Chinese middle-aged and older adults to investigate the relationship between depressive symptoms and physical function and CVD risk.
Methods: Using information from the China Health and Retirement Longitudinal Study (CHARLS), we examined the relationship between depressive symptoms, physical functioning, and CVD risk in middle-aged and older Chinese adults. The subsequent seven-year endeavor, which ran from 2011 to 2018, enrolled Chinese adults who were middle-aged and older (≥45 years). The exposures of interest were symptoms of depression and physical impairment. To measure depression symptoms, the Center for Epidemiological Studies Depression Scale (CESD-10) was used. The physical disability was ascertained using the physical mobility function. Its principal endpoint was the incidence of CVD. Cox proportional hazards regression methods has been applied to ascertain 95% of the hazard ratios (HRs) and confidence intervals (CIs). Cox multivariate regression and stratified interaction analysis analyses were employed to investigate the association between depressive symptoms, physical functioning, and CVD.
Results: A total of 1980 people were included, of whom the mean age of the participants was 56.4 ± 7.7 years, of whom 1,013 (51.2%) were women. During the maximum follow-up period of 7 years, 303 (15.3%) suffered from cardiovascular disease, of whom 246 (12.4%) had heart disease and 72 (3.6%) suffered from stroke. Compared with those with NDS (no depressive symptoms) (CESD <10) and NPD (no physical dysfunction), those with both DS (depressive symptoms) (CESD ≥10) and PD (physical dysfunction) had the highest risk of overall CVD (adjusted hazard ratio [HR], 1.88; 95% CI 1.18 to 3), coronary heart disease (HR, 2.45; 95% CI 1.44 to 4.18) and stroke (HR, 0.45; 95% CI 0.15 to 1.31), which were most common in people aged 60 years or younger.
Conclusion: This study found that older adults with DS and PD were strongly associated with an increased risk of CVD.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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