种族改变了microRNA单核苷酸多态性与儿童急性淋巴细胞白血病风险之间的关系：一项荟萃分析。

IF 1.9 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-29 DOI:10.1080/17520363.2025.2511466

Sharon Benita Antony, Julius Xavier Scott, Indhumathi Nagarthinam, Vinodhini Subramanian, Teena Koshy

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引用次数: 0

摘要

MicroRNA （miRNA）单核苷酸多态性（miRNA- snps）与儿童急性淋巴细胞白血病（ALL）有关。然而，由于这些个体研究的结果不一致，我们进行了荟萃分析，以帮助建立mirna - snp与儿科ALL风险之间的关联的统计学意义。我们还通过使用不同的遗传模型分析了它们是否在国家特定研究中赋予易感性。方法：从PubMed和谷歌Scholar数据库中收集2001 - 2023年发表的论文。通过MetaGenyo，通过合并优势比[ORs]和95% CI计算miRNA- snp与儿童ALL风险之间的关系。还对特定国家研究的合并or进行了亚组分析。结果：根据纳入和排除标准，对14项研究进行分析，提取miR146 rs2910164、miR-196a2 rs11614913、miR-612 rs12803915和mir-499 rs3746444的数据。虽然汇总数据分析没有显示任何关联，但亚组分析显示，在各种遗传模型中，所有四种mirna的等位基因频率存在国家特异性差异，这意味着基于种族的风险。结论：我们的结果表明，miRNA-SNPS仍可被视为潜在的危险因素，有待在更多人群中探索。

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Ethnicity modifies the association between microRNA single nucleotide polymorphisms and pediatric acute lymphoblastic leukemia risk: a meta-analysis.

Introduction: MicroRNA (miRNA) single nucleotide polymorphisms (miRNA-SNPs) have been associated with pediatric acute lymphoblastic leukemia (ALL). However, since the results of these individual studies have been inconsistent, we performed a meta-analysis to help establish a statistical significance for the association between miRNA-SNPs and pediatric ALL risk. We also analyzed whether they confer susceptibility across country-specific studies by using different genetic models.

Methods: Articles published from 2001 to 2023 were collected from PubMed and Google Scholar databases. Through MetaGenyo, the association between miRNA- SNPs and pediatric ALL risk was calculated by pooled odds ratio [ORs] and 95% CI. A subgroup analysis of pooled ORs in country-specific studies was also performed.

Results: Based on the inclusion and exclusion criteria, 14 studies were analyzed to extract data on miR146 rs2910164, miR-196a2 rs11614913, miR-612 rs12803915 and mir-499 rs3746444. While the pooled data analysis did not reveal any association, a subgroup analysis demonstrated country-specific differences in allele frequencies of all the four miRNAs in various genetic models, implying ethnicity-based risk.

Conclusion: Our results suggested that miRNA-SNPS can still be considered as a potential risk factor to be explored in more populations.

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来源期刊

Biomarkers in medicine 医学-医学：研究与实验

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory. Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice. As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications. Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest. Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.