类器官在探讨巨噬细胞与各种肺部疾病关系中的应用进展。

IF 8 2区医学 Q1 ENGINEERING, BIOMEDICAL

Biofabrication Pub Date : 2025-06-06 DOI:10.1088/1758-5090/adde15

Jiawang Wu, Ting Liu, Xinting Zhang, Chongchang Qu, Juan Wu, Shuanglan Xu, Jiao Yang, Xiqian Xing

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引用次数: 0

摘要

体外培养的类器官模仿体内组织和器官的特征。它们在模拟呼吸系统疾病中巨噬细胞功能方面的潜力，为研究疾病机制和治疗策略提供了新的见解，已成为研究的焦点。许多研究已经证实，类器官在解剖微生物相互作用、疾病建模、基因操作和高通量药物筛选的有效性和安全性方面具有实用价值。现就类器官在探讨巨噬细胞参与肺部疾病中的研究进展作一综述。

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Progress in the application of organoids for exploring the relationship between macrophages and various lung diseases.

Organoids culturedex vivomimicin vivotissue and organ characteristics. They have become a focus in research for their potential in modeling macrophage function in respiratory diseases, offering insights into disease mechanisms and therapeutic strategies. A number of studies have confirmed organoids' utility in dissecting microbial interactions, disease modeling, genetic manipulation, and high-throughput drug screening for efficacy and safety. This review summarizes the research progress on organoids in exploring macrophage involvement in pulmonary diseases.

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来源期刊

Biofabrication ENGINEERING, BIOMEDICAL-MATERIALS SCIENCE, BIOMATERIALS

CiteScore

17.40

自引率

3.30%

发文量

118

审稿时长

2 months

期刊介绍： Biofabrication is dedicated to advancing cutting-edge research on the utilization of cells, proteins, biological materials, and biomaterials as fundamental components for the construction of biological systems and/or therapeutic products. Additionally, it proudly serves as the official journal of the International Society for Biofabrication (ISBF).