抗胆碱能负荷与短期血压变异性关系的评估。

IF 2.8 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Cevdet Furkan Köşker, Reşit Emre Alparğan, Muhammed Ali Coşkuner, Gökhan Köker, Bilgin Bahadır Başgöz
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引用次数: 0

摘要

背景:本研究旨在探讨成人高血压患者短期血压变异性(BPV)与抗胆碱能负荷(ACB)之间的关系。方法:238例50岁及以上的高血压患者行动态血压监测。记录患者使用的药物,并采用ACB量表计算每种药物的ACB。BPV的评估基于24小时动态血压测量,采用三种方法:标准差(SD)、标准差变异系数(SD- cov)和加权标准差(wSD),日间和夜间均进行评估。结果:139例(58.40%)患者无ACB评分,64例(26.89%)患者ACB评分为1分,35例(14.71%)患者ACB评分为2分及以上。心脏病患者的ACB评分明显较高,且ACB随年龄增长而增加。然而,ACB与平均血压、夜间血压下降、Sd、Sd - cov、wSD等短期BPV参数均无统计学意义。结论:ACB与短期BPV无显著相关性。据我们所知,这是第一个调查这种关系的研究,这可能会激发进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The assessment of the relationship between anticholinergic burden and short-term blood pressure variability.

Background: This study aimed to investigate the relationship between short-term blood pressure variability (BPV) and anticholinergic burden (ACB) in adults with hypertension.

Methods: This study included 238 hypertensive patients aged 50 and older who underwent ambulatory blood pressure monitoring. The medications used by the patients were recorded, and the ACB of each medication was calculated using the ACB Scale. The BPV was assessed based on 24-hour ambulatory blood pressure measurements using three methods: standard deviation (SD), coefficient of variation of the standard deviation (SD-CoV), and weighted standard deviation (wSD), with evaluations conducted for both day-time and night-time periods.

Results: A total of 139 patients (58.40%) had no ACB score, 64 (26.89%) had an ACB score of 1, and 35 (14.71%) had an ACB score of 2 or higher. ACB scores were significantly higher among patients with heart disease, and ACB tended to increase with age. However, no statistically significant relationship was found between ACB and mean blood pressure, nocturnal blood pressure dips, or any parameters of short-term BPV including Sd, SD-CoV and wSD.

Conclusion: No significant association was found between ACB and short-term BPV. To the best of our knowledge, this is the first study to investigate this relationship, which may inspire further research.

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来源期刊
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology PHARMACOLOGY & PHARMACYTOXICOLOGY&nb-TOXICOLOGY
CiteScore
4.80
自引率
0.00%
发文量
87
审稿时长
12 weeks
期刊介绍: BMC Pharmacology and Toxicology is an open access, peer-reviewed journal that considers articles on all aspects of chemically defined therapeutic and toxic agents. The journal welcomes submissions from all fields of experimental and clinical pharmacology including clinical trials and toxicology.
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