成年雌性恒河猴(Macaca mulatta)反复迁移对皮质醇和儿茶酚胺浓度的影响

IF 2 3区 生物学 Q1 ZOOLOGY
John P. Capitanio, Daniel J. Tancredi, Jasmin Zarrabi, Catherine VandeVoort, Cheryl K. Walker
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引用次数: 0

摘要

在圈养的灵长类动物设施中,搬迁——在设施内从一个笼子搬到另一个笼子——可能是常见的事件。一方面,搬迁通常被认为是相对良性的事件,因为过去的研究一般只显示搬迁后皮质醇浓度短暂升高。另一方面,搬迁的频率与不利的健康和行为结果有关。作为研究压力对毛囊发育影响的一个更大项目的一部分,我们在3年的每一年里,每周重新安置成年雌性恒河猴几个月,并测量尿皮质醇、肾上腺素、去甲肾上腺素以及毛发皮质醇的浓度。尿皮质醇和肾上腺素的结果相似:在第1年和第3年,在重新定位开始后立即显著升高,在第1年的重新定位序列结束时浓度降低。在第二年,这两项指标没有变化。相反,在所有3年中,去甲肾上腺素浓度均升高。在第2年和第3年,毛发皮质醇浓度显著升高,这表明重排对下丘脑-垂体-肾上腺轴的持续和累积影响。总之,这些结果表明,搬迁可能不是早期研究所认为的良性事件。鉴于身体的所有器官都由交感神经系统(血液和尿液中去甲肾上腺素的主要来源)支配,并且身体细胞具有糖皮质激素和儿茶酚胺受体,我们的研究结果提示了反复迁移可能导致不良健康结果的可能机制。重复迁移可能是一个有价值的模型,实验产生适度的应力;然而,我们鼓励群体管理者和科学家尽量减少此类事件,以提高动物的福利。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cortisol and Catecholamine Concentrations Are Affected by Repeated Relocations of Adult Female Rhesus Monkeys (Macaca mulatta)

In captive primate facilities, relocations—moves, within the facility, from one cage to another—can be common events. On the one hand, relocations are generally regarded as relatively benign events, as past studies have generally shown only transient elevations in cortisol concentrations following relocation. On the other hand, the frequency of relocations has been associated with adverse health and behavioral outcomes. As part of a larger project examining the effects of stress on follicular development, we relocated adult female rhesus monkeys on a weekly basis for several months in each of 3 years, and measured concentrations of urinary cortisol, epinephrine, and norepinephrine, as well as hair cortisol. Results for urinary cortisol and epinephrine were similar: significant elevations immediately following initiation of relocations during Years 1 and 3, and reductions in concentrations by the end of the relocation sequences in Year 1. No changes were seen for these two measures in Year 2. In contrast, elevated norepinephrine concentrations were found for all 3 years. Significant elevations in hair cortisol concentrations were found for Years 2 and 3, and suggested persisting and cumulative effects of relocations on the hypothalamic−pituitary−adrenal axis. Together, these results suggest that relocations may not be the benign events suggested by earlier studies. Given that all organs of the body are innervated by the sympathetic nervous system (the principal source of norepinephrine in blood and urine) and that cells of the body have glucocorticoid and catecholamine receptors, our results suggest possible mechanisms by which repeated relocations may result in adverse health outcomes. Repeated relocations may be a valuable model for experimentally generating moderate stress; however, we encourage colony managers and scientists to minimize such events to enhance the welfare of the animals.

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来源期刊
CiteScore
4.50
自引率
8.30%
发文量
103
审稿时长
4-8 weeks
期刊介绍: The objective of the American Journal of Primatology is to provide a forum for the exchange of ideas and findings among primatologists and to convey our increasing understanding of this order of animals to specialists and interested readers alike. Primatology is an unusual science in that its practitioners work in a wide variety of departments and institutions, live in countries throughout the world, and carry out a vast range of research procedures. Whether we are anthropologists, psychologists, biologists, or medical researchers, whether we live in Japan, Kenya, Brazil, or the United States, whether we conduct naturalistic observations in the field or experiments in the lab, we are united in our goal of better understanding primates. Our studies of nonhuman primates are of interest to scientists in many other disciplines ranging from entomology to sociology.
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