肠道微生物-丁酸酯- ppar γ轴调节脂肪调节性T细胞群（Adv. Sci. 20/2025）

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-05-29 DOI:10.1002/advs.202570151

Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu

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引用次数: 0

摘要

肠道微生物-丁酸盐-PPARγ本研究表明，肠道微生物来源的丁酸盐通过激活PPARγ促进脂肪ST2+调节性T细胞群。封面插图描绘了肠道微生物群（用橙色形状的细菌细胞表示）释放丁酸盐（用蓝色颗粒和蓝色分子结构表示），丁酸盐传递电信号激活脂肪组织（橙色细胞）中的ST2+调节性T细胞（紫色显示），突出了它们在维持脂肪组织免疫稳态中的作用。更多的细节可以在2411086号文章中找到王维清，刘瑞新和同事。封面设计：Rui Xie

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gut Microbiota-Butyrate-PPARγ Axis Modulates Adipose Regulatory T Cell Population (Adv. Sci. 20/2025)

Gut Microbiota-Butyrate-PPARγ

This study demonstrates that gut microbiota-derived butyrate promotes adipose ST2⁺ regulatory T cell population through PPARγ activation. The cover illustration depicts gut microbiota (represented by orange-shaped bacterial cells) releasing butyrate (represented as blue particles and blue molecular structures), which transmit electrical-like signals to activate ST2⁺ regulatory T cells (shown in purple) in adipose tissue (orange cells), highlighting their role in maintaining adipose tissue immune homeostasis. More details can be found in article number 2411086 by Weiqing Wang, Ruixin Liu, and co-workers. Cover design by Rui Xie.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.