化学修饰的非编码RNA结构域递送改善营养不良肌管功能（Adv. Sci. 20/2025）

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-05-29 DOI:10.1002/advs.202570150

Zeinabou Niasse-Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar-Nur, Johan Auwerx, Martin Wohlwend

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引用次数: 0

摘要

肌肉RNACYTOR是骨骼肌中的促肌长链非编码RNA。化学探测CYTOR发现外显子2是一个独立的肌生成结构域，促进肌肉功能。肌原性外显子2 RNA的化学工程改善了药理学特性（RNA稳定性、免疫原性），化学增强的合成RNA结构域的递送改善了源自杜氏肌营养不良患者的肌管的疾病特征。更多细节可以在Martin Wohlwend和同事的2410908号文章中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function (Adv. Sci. 20/2025)

查看原文本刊更多论文

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function (Adv. Sci. 20/2025)

Muscle RNA

CYTOR is a pro-myogenic long noncoding RNA in skeletal muscle. Chemical probing of CYTOR identifies exon 2 as an independent myogenic domain that promotes muscle function. Chemical engineering of the myogenic exon 2 RNA improves pharmacologic properties (RNA stability, immunogenicity) and delivery of the chemically-enhanced, synthetic RNA domain improves disease characteristics in myotubes derived from Duchenne muscular dystrophy patients. More details can be found in article number 2410908 by Martin Wohlwend and co-workers.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.