人类PDAC中癌症相关成纤维细胞的转录组图谱（Adv. Sci. 20/2025）

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-05-29 DOI:10.1002/advs.202570155

Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang

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引用次数: 0

摘要

在胰腺导管腺癌（PDAC）的进展过程中，癌症相关成纤维细胞（CAFs）发生动态变化，就像藤蔓附着在树上一样。带刺藤蔓代表CDCP1+FTL+ CAFs，表现出对铁下垂诱导剂（以啄木鸟为标志）的抗性。同时，CAFs分泌各种趋化因子，类似于藤上的花朵吸引蝴蝶，从而促进髓细胞的浸润。更多的细节可以在2415196号文章中找到，作者是周诚、谭曙光、郑宇轩、王红霞和同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Transcriptome Landscape of Cancer-Associated Fibroblasts in Human PDAC (Adv. Sci. 20/2025)

Cancer Associated Fibroblasts in Human PDAC

During pancreatic ductal adenocarcinoma (PDAC) progression, cancer-associated fibroblasts (CAFs) undergo dynamic changes, much like vines clinging to trees. The thorny vines represent CDCP1+FTL+ CAFs, which exhibit resistance to ferroptosis inducers (symbolized by the woodpecker). Simultaneously, CAFs secrete various chemokines, akin to blossoms on vines attracting butterflies, thereby promoting the infiltration of myeloid cells. More details can be found in article number 2415196 by Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang, and co-workers.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.