Changhao Que, Qi Wang, Zhibo Ye, Peiyuan Lu, Chengfang Li, Dacheng Jin, Yaping Wang, Yunjiu Gou
{"title":"部分肺切除术与肺叶切除术对结直肠癌分离性肺转移患者的治疗效果：来自回顾性队列研究的证据","authors":"Changhao Que, Qi Wang, Zhibo Ye, Peiyuan Lu, Chengfang Li, Dacheng Jin, Yaping Wang, Yunjiu Gou","doi":"10.1155/ijcp/9035094","DOIUrl":null,"url":null,"abstract":"<div>\n <p><b>Introduction:</b> In patients with solitary pulmonary metastasis from colorectal cancer, surgical resection is considered a standard treatment protocol and is routinely performed in thoracic surgery. However, there is a paucity of studies that delve into the detailed discussion of the efficacy and safety of lobectomy and segmentectomy in the treatment of pulmonary metastatic cancer. Our study retrospectively analyzed the surgical outcomes of 62 patients from a single center and reported the findings.</p>\n <p><b>Methods:</b> A retrospective analysis was meticulously conducted on a cohort of 62 patients who underwent either lung segmental resection (<i>n</i> = 31) or lobectomy (<i>n</i> = 31) for isolated lung metastases at the department of thoracic surgery of Gansu Provincial People’s Hospital, spanning a decade from September 2015 to September 2024. The surgical data were thoroughly examined, encompassing perioperative details and patient outcomes.</p>\n <p><b>Results:</b> Both surgical approaches achieved successful resection of colorectal cancer lung metastases, without any perioperative mortality reported. In comparison to the group undergoing lung segmental resection, the cohort receiving lobectomy exhibited significantly larger tumor diameters (<i>p</i> < 0.001), prolonged operative durations (<i>p</i> < 0.001), increased intraoperative bleeding (<i>p</i> = 0.002), augmented drainage volume on the first postoperative day (<i>p</i> < 0.001), greater total postoperative drainage (<i>p</i> < 0.001), and elevated operative costs (<i>p</i> < 0.001). However, there were no statistically significant differences between the two groups regarding postoperative pain scores (<i>p</i> = 0.755), time to postoperative extubation (<i>p</i> = 0.744), time to postoperative ambulation (<i>p</i> = 0.742), duration of postoperative hospital stay (<i>p</i> = 0.870), lymph node metastasis (<i>p</i> = 0.671), postoperative complications (<i>p</i> = 0.562), survival rate (<i>p</i> = 0.550), recurrence-free survival rate (<i>p</i> = 0.450), and cumulative incidence (<i>p</i> = 0.321).</p>\n <p><b>Conclusions:</b> Pulmonary segmentectomy offers superior advantages in terms of operative time, intraoperative blood loss, drainage volume on the first postoperative day, total postoperative drainage volume, and surgical costs.</p>\n </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9035094","citationCount":"0","resultStr":"{\"title\":\"The Therapeutic Effectiveness of Segmental Lung Resection Versus Lobectomy in Patients With Isolated Lung Metastases From Colorectal Cancer: Evidence From a Retrospective Cohort Study\",\"authors\":\"Changhao Que, Qi Wang, Zhibo Ye, Peiyuan Lu, Chengfang Li, Dacheng Jin, Yaping Wang, Yunjiu Gou\",\"doi\":\"10.1155/ijcp/9035094\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n <p><b>Introduction:</b> In patients with solitary pulmonary metastasis from colorectal cancer, surgical resection is considered a standard treatment protocol and is routinely performed in thoracic surgery. However, there is a paucity of studies that delve into the detailed discussion of the efficacy and safety of lobectomy and segmentectomy in the treatment of pulmonary metastatic cancer. Our study retrospectively analyzed the surgical outcomes of 62 patients from a single center and reported the findings.</p>\\n <p><b>Methods:</b> A retrospective analysis was meticulously conducted on a cohort of 62 patients who underwent either lung segmental resection (<i>n</i> = 31) or lobectomy (<i>n</i> = 31) for isolated lung metastases at the department of thoracic surgery of Gansu Provincial People’s Hospital, spanning a decade from September 2015 to September 2024. The surgical data were thoroughly examined, encompassing perioperative details and patient outcomes.</p>\\n <p><b>Results:</b> Both surgical approaches achieved successful resection of colorectal cancer lung metastases, without any perioperative mortality reported. In comparison to the group undergoing lung segmental resection, the cohort receiving lobectomy exhibited significantly larger tumor diameters (<i>p</i> < 0.001), prolonged operative durations (<i>p</i> < 0.001), increased intraoperative bleeding (<i>p</i> = 0.002), augmented drainage volume on the first postoperative day (<i>p</i> < 0.001), greater total postoperative drainage (<i>p</i> < 0.001), and elevated operative costs (<i>p</i> < 0.001). However, there were no statistically significant differences between the two groups regarding postoperative pain scores (<i>p</i> = 0.755), time to postoperative extubation (<i>p</i> = 0.744), time to postoperative ambulation (<i>p</i> = 0.742), duration of postoperative hospital stay (<i>p</i> = 0.870), lymph node metastasis (<i>p</i> = 0.671), postoperative complications (<i>p</i> = 0.562), survival rate (<i>p</i> = 0.550), recurrence-free survival rate (<i>p</i> = 0.450), and cumulative incidence (<i>p</i> = 0.321).</p>\\n <p><b>Conclusions:</b> Pulmonary segmentectomy offers superior advantages in terms of operative time, intraoperative blood loss, drainage volume on the first postoperative day, total postoperative drainage volume, and surgical costs.</p>\\n </div>\",\"PeriodicalId\":13782,\"journal\":{\"name\":\"International Journal of Clinical Practice\",\"volume\":\"2025 1\",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-05-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9035094\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Clinical Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1155/ijcp/9035094\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/ijcp/9035094","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
The Therapeutic Effectiveness of Segmental Lung Resection Versus Lobectomy in Patients With Isolated Lung Metastases From Colorectal Cancer: Evidence From a Retrospective Cohort Study
Introduction: In patients with solitary pulmonary metastasis from colorectal cancer, surgical resection is considered a standard treatment protocol and is routinely performed in thoracic surgery. However, there is a paucity of studies that delve into the detailed discussion of the efficacy and safety of lobectomy and segmentectomy in the treatment of pulmonary metastatic cancer. Our study retrospectively analyzed the surgical outcomes of 62 patients from a single center and reported the findings.
Methods: A retrospective analysis was meticulously conducted on a cohort of 62 patients who underwent either lung segmental resection (n = 31) or lobectomy (n = 31) for isolated lung metastases at the department of thoracic surgery of Gansu Provincial People’s Hospital, spanning a decade from September 2015 to September 2024. The surgical data were thoroughly examined, encompassing perioperative details and patient outcomes.
Results: Both surgical approaches achieved successful resection of colorectal cancer lung metastases, without any perioperative mortality reported. In comparison to the group undergoing lung segmental resection, the cohort receiving lobectomy exhibited significantly larger tumor diameters (p < 0.001), prolonged operative durations (p < 0.001), increased intraoperative bleeding (p = 0.002), augmented drainage volume on the first postoperative day (p < 0.001), greater total postoperative drainage (p < 0.001), and elevated operative costs (p < 0.001). However, there were no statistically significant differences between the two groups regarding postoperative pain scores (p = 0.755), time to postoperative extubation (p = 0.744), time to postoperative ambulation (p = 0.742), duration of postoperative hospital stay (p = 0.870), lymph node metastasis (p = 0.671), postoperative complications (p = 0.562), survival rate (p = 0.550), recurrence-free survival rate (p = 0.450), and cumulative incidence (p = 0.321).
Conclusions: Pulmonary segmentectomy offers superior advantages in terms of operative time, intraoperative blood loss, drainage volume on the first postoperative day, total postoperative drainage volume, and surgical costs.
期刊介绍：
IJCP is a general medical journal. IJCP gives special priority to work that has international appeal.
IJCP publishes:
Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion]
Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion]
Study design and interpretation. Example. [Always peer reviewed]
Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed]
Meta-analyses. [Always peer reviewed]
Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed]
Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed]
''How to…'' papers. Example. [Always peer reviewed]
Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed]
Letters. [Peer reviewed at the editor''s discretion]
International scope
IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.
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