代谢健康和体重变化对COVID-19风险的影响：一项基于人群的队列研究

IF 3.9 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Public Health Pub Date : 2025-05-30 DOI:10.1016/j.puhe.2025.105777

Yujin Park , Su Hwan Kim , Ahnul Ha , Young Kook Kim , Hyung-Jin Yoon , Jae-Heon Kang , So-Eun Kim , Yoon Ji Kim , Ye Seul Bae

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引用次数: 0

摘要

目的肥胖和代谢健康是影响COVID-19严重程度的已知因素。然而，代谢健康和体重状况的变化对COVID-19结局的影响尚不清楚。调查代谢健康和体重状况随时间变化与covid -19相关风险之间的关系。研究设计：基于人群的回顾性队列研究。方法：这项基于人群的回顾性队列研究使用了2014年1月至2021年12月期间收集的韩国国家卫生信息服务中心的数据。在2014-2015年和2016-2017年接受健康筛查的284,719名参与者被分为代谢健康非肥胖（MHNO）组、代谢健康肥胖（MHO）组、代谢不健康非肥胖（MUNO）组和代谢不健康肥胖（MUO）组。结果在初始MHNO参与者中，成为MHO（危险比（HR）为1.082,95%可信区间为1.01 ~ 1.16）和MUO（1.18、1.11 ~ 1.26）的患者与保持MHNO的患者相比，罹患COVID-19的风险较高。相反，从MUO过渡到MUNO（0.89、0.84 - 0.95）的参与者患COVID-19的风险较低。代谢健康的改善并没有减轻与covid -19相关的风险。从MHNO过渡到MHO（3.57, 1.38 - 9.26）与COVID-19死亡风险显著升高相关。结论代谢健康和肥胖状况的变化对COVID-19结局有显著影响。解决肥胖问题和促进代谢健康对于减轻COVID-19的影响至关重要。

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Impact of metabolic health and weight transition on COVID-19 risk: A population-based cohort study

Objectives

Obesity and metabolic health are known factors influencing COVID-19 severity. However, the effect of changes in metabolic health and weight status on COVID-19 outcomes remains unclear. To investigate the association between changes in metabolic health and weight status over time and COVID-19-related risks.

Study design

Retrospective population-based cohort study.

Methods

This retrospective population-based cohort study used data from South Korea's National Health Information Service collected between January 2014 and December 2021. A total of 284,719 participants who underwent health screening both in 2014–2015 and 2016–2017 were divided into the metabolically healthy non-obese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy non-obese (MUNO), and metabolically unhealthy obese (MUO) groups.

Results

Among initial MHNO participants, those who became MHO (hazard ratio (HR) 1·082, 95 % confidence intervals 1·01–1·16) and MUO (1·18, 1·11–1·26) had elevated risk for COVID-19 compared with those who remained MHNO. Conversely, participants who transitioned from MUO to MUNO (0·89, 0·84–0·95) were associated with a lower risk of COVID-19. Improvements in metabolic health did not mitigate COVID-19-related risks. Transitioning from MHNO to MHO (3·57, 1·38–9·26) was associated with a significantly higher risk of death due to COVID-19.

Conclusions

Changes in metabolic health and obesity status significantly influence COVID-19 outcomes. Addressing obesity and promoting metabolic health are critical for mitigating the impact of COVID-19.

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来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.