血清omega-3多不饱和脂肪酸与载脂蛋白B和致动脉粥样硬化脂蛋白脂质的关系

IF 3.6 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of clinical lipidology Pub Date : 2025-05-01 DOI:10.1016/j.jacl.2025.04.085

Meredith Wilcox MPH, Liana Guarneiri PhD, Peter Attia MD, David Allison PhD, Kevin Maki PhD, Carol Kirkpatrick PhD

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引用次数: 0

摘要

印第安纳大学基金会资助了这项研究。背景/摘要观察性证据支持高摄入omega-3多不饱和脂肪酸（PUFAs），主要是二十碳五烯酸和二十二碳六烯酸（DHA）与降低动脉粥样硬化性心血管疾病风险之间的关联。血清中omega-3 PUFAs的水平与饮食摄入量有关。目的/目的：研究SARS-CoV-2感染后免疫学和其他生物标志物的变化。通过对Aegis队列基线数据的横断面分析，研究了血清总omega-3 PUFA和DHA水平与心血管风险的选定生物标志物（包括载脂蛋白B （apoB）和脂蛋白脂浓度）之间的关系。方法评估基线空腹血清omega-3 PUFAs、载脂蛋白ob、低密度脂蛋白胆固醇（LDL-C）、非高密度脂蛋白胆固醇（non-HDL-C）和甘油三酯水平。采用多变量线性模型，以体重指数（BMI）、年龄和性别为协变量，评估血清脂肪酸生物标志物水平在五分位数类别中的变化趋势。结果分析纳入了1894名可获得相关生物标志物数据的参与者（65%为女性，平均年龄：50岁，平均BMI: 29.0 kg/m2, 62%非西班牙裔白人，11%黑人/非裔美国人，7%西班牙裔/拉丁裔，10%亚洲人，10%混合/其他）。总omega-3 PUFAs占总循环脂肪酸百分比的第20和第80百分位数分别为3.00%和4.73%，DHA分别为1.51%和2.26%。血清omega-3 PUFA水平五分位数(Q)1和Q5的最小二乘几何均数（LSGMs）分别为：apoB、94.0和98.0 (P = 0.047)；LDL-C为102、105 (P = 0.381)；非hdl - c， 124和128 (P = 0.283)；甘油三酯为99.2和105 （P = 0.055）。血清DHA水平Q1和Q5的LSGMs分别为：apoB、103和91.4；LDL-C分别为114和97.5；非hdl - c， 143和116；甘油三酯分别为152和80.1 (P <；0.001)。结论较高的血清DHA水平与较低的载脂蛋白ob、LDL-C、非hdl - c和甘油三酯浓度有关。相反，较高的血清总omega-3 PUFA水平与较高的载脂蛋白ob浓度适度相关，与其他脂蛋白脂类生物标志物无显著关系，突出了特定omega-3 PUFA的潜在差异关系。

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Associations of serum omega-3 polyunsaturated fatty acids with apolipoprotein B and atherogenic lipoprotein lipids

Funding

The Indiana University Foundation funded this research.

Background/Synopsis

Observational evidence supports associations between higher intakes of omega-3 polyunsaturated fatty acids (PUFAs), primarily eicosapentaenoic acid and docosahexaenoic acid (DHA), and reduced risk for atherosclerotic cardiovascular disease. Serum levels of omega-3 PUFAs correlate with dietary intakes.

Objective/Purpose

Aegis was a prospective cohort study that investigated immunological and other biomarker changes after incident severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This cross-sectional analysis of baseline data from the Aegis cohort examined the relationships between serum total omega-3 PUFA and DHA levels and selected biomarkers of cardiovascular risk, including apolipoprotein B (apoB) and lipoprotein lipid concentrations.

Methods

Baseline fasting serum levels of omega-3 PUFAs, apoB, low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and triglycerides were assessed. Multivariate linear models were used to assess trends in biomarker levels across quintile categories of serum fatty acids with body mass index (BMI), age, and sex as covariates.

Results

Analyses included 1894 participants for whom relevant biomarker data were available (65% female, mean age: 50 y, mean BMI: 29.0 kg/m², 62% Non-Hispanic White, 11% Black/African American, 7% Hispanic/Latino, 10% Asian, 10% mixed/other). The 20^th and 80^th percentiles for total omega-3 PUFAs as a percentage of total circulating fatty acids were 3.00% and 4.73%, respectively, and for DHA were 1.51% and 2.26%, respectively. Least squares geometric means (LSGMs) in mg/dL for serum omega-3 PUFA level quintile (Q)1 and Q5, respectively, were: apoB, 94.0 and 98.0 (P = 0.047); LDL-C, 102 and 105 (P = 0.381); non-HDL-C, 124 and 128 (P = 0.283); and triglycerides, 99.2 and 105 (P = 0.055). LSGMs for serum DHA level Q1 and Q5, respectively, were: apoB, 103 and 91.4; LDL-C, 114 and 97.5; non-HDL-C, 143 and 116; and triglycerides, 152 and 80.1 (all P < 0.001).

Conclusions

A higher serum DHA level was linked to lower apoB, LDL-C, non-HDL-C, and triglyceride concentrations. In contrast, a higher serum total omega-3 PUFA level was modestly associated with a higher apoB concentration and showed no significant relationships with other lipoprotein lipid biomarkers, highlighting potential differential relationships for specific omega-3 PUFAs.

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来源期刊

Journal of clinical lipidology 医学-药学

CiteScore

7.00

自引率

6.80%

发文量

209

审稿时长

49 days

期刊介绍： Because the scope of clinical lipidology is broad, the topics addressed by the Journal are equally diverse. Typical articles explore lipidology as it is practiced in the treatment setting, recent developments in pharmacological research, reports of treatment and trials, case studies, the impact of lifestyle modification, and similar academic material of interest to the practitioner. Sections of Journal of clinical lipidology will address pioneering studies and the clinicians who conduct them, case studies, ethical standards and conduct, professional guidance such as ATP and NCEP, editorial commentary, letters from readers, National Lipid Association (NLA) news and upcoming event information, as well as abstracts from the NLA annual scientific sessions and the scientific forums held by its chapters, when appropriate.