前交叉韧带重建后个体的一种新的机械敏感应力测试：一项初步研究

Osteoarthritis and cartilage open Pub Date : 2025-05-09 DOI:10.1016/j.ocarto.2025.100619

Prakash Jayabalan , Rose Darcy , Vikram Darbhe , Zander Neuville , Vehniah Tjong , Levi Hargrove , Leah Welty , Thomas Schnitzer

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引用次数: 0

摘要

Objectives1。评估前交叉韧带重建（ACLR）膝关节与未损伤的对侧膝关节在侧倾斜模式下的血清生物标志物反应。2. 确定ACLR膝关节运动学与血清生物标志物反应之间的关系。MethodCross-sequential研究。16名参与者在ACLR后2-7年，在10°角度倾斜的跑步机上对ACLR膝关节和/或对侧未受伤的膝关节进行两次30分钟的步行。在基线和步行30分钟后收集血清，检测与骨关节炎相关的生物标志物（软骨寡聚基质蛋白[COMP]）、II型胶原c端交联末端肽、基质金属蛋白酶-3、-13、adama崩解素和血小板反应蛋白基元4-、-5 （ADAMTS-4、-5）、白细胞介素-1β、-6、-8和RANTES（受激活调节，正常t细胞表达和分泌）。还进行了运动学测量。结果当向ACLR膝关节倾斜时，与基线相比，COMP显著增加(平均41.1 ng/mL (95%CI:13.8,68.4)，而向对侧膝关节倾斜时未观察到COMP。COMP浓度变化与膝关节内收/外展角度变化有显著相关性（r = - 0.58,p = 0.02）。与运动学和其他生物标志物没有关系。结论：倾斜模式在检测ACLR和对侧膝关节时发现了血清机械敏感标志物（COMP）的差异反应。COMP对倾斜行走的反应与ACLR膝关节内收角的变化也有显著关系。对于aclr术后至少2年有发生创伤后骨关节炎风险的无症状个体，该模型有助于提供个体膝关节生物标志物对机械应力的反应。

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A novel mechanosensitive stress test in individuals following anterior cruciate ligament reconstruction: A pilot study

Objectives

1. Assess serum biomarker responses of the anterior cruciate ligament reconstructed (ACLR) knee compared to the non-injured contralateral knee in a lateral tilt paradigm. 2. Determine the relationship between kinematics at the ACLR knee and serum biomarker responses.

Method

Cross-sequential study. 16 participants 2–7 years post-ACLR, undertook two 30 min walking sessions on a 10° angular tilted treadmill towards the ACLR knee and/or contralateral non-injured knee. Serum collected at baseline and after 30 min of walking was tested for biomarkers associated with osteoarthritis (Cartilage oligomeric matrix protein [COMP]), C-terminal cross-linked telopeptides of type II collagen, matrix metalloproteinase-3,-13, ADAM a disintegrin and metalloproteinase with thrombospondin motifs 4-,-5 (ADAMTS-4,-5), interleukin-1β,-6,-8 and RANTES (regulated on activation, normal T-cell expressed and secreted). Kinematic measurements were also taken.

Results

When tilted towards the ACLR knee, there was a significant increase in COMP compared to baseline (mean 41.1 ng/mL (95%CI:13.8,68.4), not observed when tilted towards the contralateral knee. There was a significant correlation between change in COMP concentration and change in knee adduction/abduction angle (r = −0.58,p = 0.02). There were no relationships to kinematics and the other biomarkers.

Conclusions

The tilt paradigm identified a differential response of a serum mechanosensitive marker (COMP) when testing an ACLR and contralateral knee. There was also a significant relationship between COMP response to tilt walking and the change in knee adduction angle of the ACLR knee. This paradigm could be an aid to provide individual knee biomarker response to a mechanical stress in asymptomatic individuals at risk of developing post-traumatic osteoarthritis at least 2 years post-ACLR.

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来源期刊

Osteoarthritis and cartilage open Orthopedics, Sports Medicine and Rehabilitation

CiteScore

3.30

自引率

0.00%

发文量