皮肤传染病用胶体给药系统

IF 4.2 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2025-05-10 DOI:10.1016/j.coph.2025.102536

Sopan Nangare , Varda Joshi , Shrikant Magdum , Riya Patil , Vishin Patil

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引用次数: 0

摘要

传染性皮肤病是全球主要的健康负担，需要有效和负担得起的治疗。传统疗法经常面临生物利用度降低、酶降解、渗透性低和溶解度差等挑战。基于胶体的透皮给药系统，包括脂质体、脂质体、乳质体、纳米乳液、聚合纳米颗粒、胶束、固体脂质纳米颗粒等，已经成为有希望的替代方案。简而言之，这些胶体系统增强了药物的渗透、稳定性、生物相容性和定制释放，同时提高了对各种病原体的抗菌功效，并最大限度地减少了全身副作用。总之，胶体制剂提供了一种有针对性的、有效的方法，优化了治疗结果，提高了患者的依从性，并推进了传染性皮肤病的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Colloidal drug delivery systems for infectious diseases of skin

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Colloidal drug delivery systems for infectious diseases of skin

Infectious skin diseases represent a major global health burden, demanding effective and affordable treatments. Conventional therapies often face challenges such as reduced bioavailability, enzymatic degradation, low permeability, and poor solubility. Colloidal-based transdermal drug delivery systems, including liposomes, ethosomes, niosomes, nanoemulsions, polymeric nanoparticles, micelles, solid lipid nanoparticles, etc., have emerged as promising alternatives. In brief, these colloidal systems enhance drug penetration, stability, biocompatibility, and customized release while improving antimicrobial efficacy against various pathogens and minimizing systemic side effects. In conclusion, colloidal formulations offer a targeted, efficient approach, optimizing therapeutic outcomes, improving patient compliance, and advancing the treatment of infectious skin diseases.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.