功能性近红外光谱(fNIRS)检测阿尔茨海默病及相关痴呆患者的冷漠和疼痛的大脑变化:一项探索性研究

Q4 Neuroscience
Allison J. Huff , Juyoung Park , Samuel Montero-Hernandez , Lindsey Park , Chiyoung Lee , Luca Pollonini , Hyochol Ahn
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引用次数: 0

摘要

阿尔茨海默病和相关痴呆(ADRD)本质上是退行性和进行性的,通常伴有慢性疼痛和神经精神症状,这些症状可能是ADRD的早期症状和加重因素。本探索性研究探讨了自我报告的疼痛、神经精神症状和疼痛诱发的皮层血流动力学变化之间的关系,采用功能性近红外光谱(fNIRS)在双侧前额叶和初级运动和体感大脑皮层进行测量,并按认知功能高低分层。本研究分析了40例轻度至中度ADRD伴膝骨关节炎患者的基线数据。分析了40例轻度至中度ADRD和膝关节骨关节炎患者的基线数据。测量包括自我报告的疼痛、抑郁和冷漠,以及fnirs衍生的脑血流动力学对亚阈值热痛刺激在五个脑区域的反应。研究显示,与认知功能低下相关的右前额叶皮层的氧合血红蛋白与冷漠呈显著负相关(p = 0.04),与认知功能较高相关的右体感区氧合血红蛋白与冷漠呈显著正相关(p = 0.04),与认知功能较高相关的内侧前额叶皮层的氧合血红蛋白与疼痛呈显著正相关(p = 0.04)。研究结果表明,fNIRS可能为ADRD和慢性骨关节炎疼痛患者的冷漠和抑郁提供有价值的生物标志物,基于认知功能的不同模式,表明神经精神症状可能因患者的认知状态而不同。未来的研究应探索其在更大、更多样化的样本和针对神经精神症状的临床干预中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Functional near-infrared spectroscopy (fNIRS) detects brain changes for apathy and pain in patients with Alzheimer's disease and related dementias: An exploratory study
Alzheimer's Disease and Related Dementias (ADRD) are degenerative and progressive in nature and are often accompanied by chronic pain and neuropsychiatric symptoms, which can be early signs and aggravators of ADRD. This exploratory study explores the relationship between self-reported pain, neuropsychiatric symptoms, and pain-evoked cortical hemodynamic changes measured using functional near-infrared spectroscopy (fNIRS) in the prefrontal and primary motor and somatosensory brain cortices bilaterally, stratified by high or low cognitive function in individuals with ADRD. This study analyzed baseline data of 40 individuals with mild to moderate ADRD with knee osteoarthritis.
Baseline data from 40 individuals with mild to moderate ADRD and knee osteoarthritis were analyzed. Measures included self-reported pain, depression, and apathy, along with fNIRS-derived cerebral hemodynamic responses to sub-threshold thermal pain stimulation across five brain regions. The study revealed significant negative correlations for oxyhemoglobin and apathy in the right prefrontal cortex associated with low cognitive function (p = .04) and significant positive correlations for oxyhemoglobin and apathy in the right somatosensory region (p = .04) and for oxyhemoglobin and pain in the medial prefrontal cortex (p = .04) associated with higher cognitive function. Study findings suggest that fNIRS may provide valuable biomarkers for apathy and depression in individuals with ADRD and chronic osteoarthritic pain, with differential patterns based on cognitive function, suggesting neuropsychiatric symptoms may manifest differently depending on the patient's cognitive status. Future studies should explore its utility in larger, diverse samples and clinical interventions targeting neuropsychiatric symptoms.
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来源期刊
Neuroimage. Reports
Neuroimage. Reports Neuroscience (General)
CiteScore
1.90
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0.00%
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审稿时长
87 days
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