Multimodal sensing platform based on Fe3O4/DEX/PDA@Au(Raman reporters)@Au nanocomposites for sweat biomarkers monitoring

This paper introduces a highly sensitive and non-invasive Fe₃O₄/DEX/PDA@Au(Raman reporters)@Au (FDPA(Raman reporters)A) surface-enhanced Raman scattering (SERS) and colorimetric dual mode sensor. 5,5′- dithiobis (2-nitrobenzoic acid) (DTNB) was identified as the optimized Raman reporters in the FDPAA core–shell structures. To quantitative analysis of lactate and glucose captured from human sweat, we utilized magnet to enrich the FDPA(DTNB)A-lactate/glucose composites generated by the reaction. This design leverages the hydrophilic viscose fiber as microfluidic flow to concentrate analytes, substantially improving the detection sensitivity. This sensing platform reached noninvasive monitoring limits for glucose and lactate acid as 5 × 10⁻⁷ M and 10⁻⁶ M in sweat. This sensing platform responses to mutual-interfering, maintaining capacity, and bio-compatibility was estimated, expressing high reliable and precision. This FDPA(DTNB)A dual mode sensing platform shows easily manufacture, and great reliable and sensitivity, exhibiting vital potential for biosensor and medical research. The advancements are expected to encourage real utility of SERS-based sensing platform, hinting vast future application.