Luisa Coderch , Lucia Ricci , Meritxell Martí , Saman Bagherpour , Lluïsa Pérez-García , Cristina Alonso
{"title":"用于防水粘膜的脂质体配方","authors":"Luisa Coderch , Lucia Ricci , Meritxell Martí , Saman Bagherpour , Lluïsa Pérez-García , Cristina Alonso","doi":"10.1016/j.ejpb.2025.114757","DOIUrl":null,"url":null,"abstract":"<div><div>Liposome formulations consisting of lipids contained in the stratum corneum have been recently demonstrated to decrease the permeability of mucosae. The permeability barrier of the mucosa is dependent on the presence of specific lipids. The main objective of this work is to reinforce the barrier effect of the oral mucosa with liposomal formulations to decrease permeation. Due to the high similarity in composition and structure between lanolin and human stratum corneum lipids, liposomes were formed with lipids contained in the stratum corneum with two kinds of ceramide or with lanolin. Transmembrane water loss of the two formulations was assessed, obtaining an important diminution for both liposomal formulations. Caffeine, lidocaine, ketoprofen and ivermectin and a virus model were tested on mucosa and on modified mucosa to evaluate the liposomal efficacy.</div><div>A somewhat consistent permeation pattern was obtained for the different membranes: caffeine > lidocaine > ketoprofen > ivermectin. For all drugs and for the virus model, the most effective formulation was the liposomal formulation, consisting of lipids found in the horny layer of the skin. The effect of the lanolin on the transmembrane water loss is not reflected on the drug permeation. Therefore, it is demonstrated the main role of ceramides in the barrier function for drugs and a virus model. Strengthening the barrier function of the mucosa promotes the prevention or reduction of the permeation of different actives, which could be to extrapolate to harmful actives like viruses, pollutants, toxins, contaminants, etc.</div></div>","PeriodicalId":12024,"journal":{"name":"European Journal of Pharmaceutics and Biopharmaceutics","volume":"213 ","pages":"Article 114757"},"PeriodicalIF":4.3000,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Liposomal formulations for waterproofing mucosal membranes\",\"authors\":\"Luisa Coderch , Lucia Ricci , Meritxell Martí , Saman Bagherpour , Lluïsa Pérez-García , Cristina Alonso\",\"doi\":\"10.1016/j.ejpb.2025.114757\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Liposome formulations consisting of lipids contained in the stratum corneum have been recently demonstrated to decrease the permeability of mucosae. The permeability barrier of the mucosa is dependent on the presence of specific lipids. The main objective of this work is to reinforce the barrier effect of the oral mucosa with liposomal formulations to decrease permeation. Due to the high similarity in composition and structure between lanolin and human stratum corneum lipids, liposomes were formed with lipids contained in the stratum corneum with two kinds of ceramide or with lanolin. Transmembrane water loss of the two formulations was assessed, obtaining an important diminution for both liposomal formulations. Caffeine, lidocaine, ketoprofen and ivermectin and a virus model were tested on mucosa and on modified mucosa to evaluate the liposomal efficacy.</div><div>A somewhat consistent permeation pattern was obtained for the different membranes: caffeine > lidocaine > ketoprofen > ivermectin. For all drugs and for the virus model, the most effective formulation was the liposomal formulation, consisting of lipids found in the horny layer of the skin. The effect of the lanolin on the transmembrane water loss is not reflected on the drug permeation. Therefore, it is demonstrated the main role of ceramides in the barrier function for drugs and a virus model. Strengthening the barrier function of the mucosa promotes the prevention or reduction of the permeation of different actives, which could be to extrapolate to harmful actives like viruses, pollutants, toxins, contaminants, etc.</div></div>\",\"PeriodicalId\":12024,\"journal\":{\"name\":\"European Journal of Pharmaceutics and Biopharmaceutics\",\"volume\":\"213 \",\"pages\":\"Article 114757\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-05-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Pharmaceutics and Biopharmaceutics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0939641125001341\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Pharmaceutics and Biopharmaceutics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0939641125001341","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Liposomal formulations for waterproofing mucosal membranes
Liposome formulations consisting of lipids contained in the stratum corneum have been recently demonstrated to decrease the permeability of mucosae. The permeability barrier of the mucosa is dependent on the presence of specific lipids. The main objective of this work is to reinforce the barrier effect of the oral mucosa with liposomal formulations to decrease permeation. Due to the high similarity in composition and structure between lanolin and human stratum corneum lipids, liposomes were formed with lipids contained in the stratum corneum with two kinds of ceramide or with lanolin. Transmembrane water loss of the two formulations was assessed, obtaining an important diminution for both liposomal formulations. Caffeine, lidocaine, ketoprofen and ivermectin and a virus model were tested on mucosa and on modified mucosa to evaluate the liposomal efficacy.
A somewhat consistent permeation pattern was obtained for the different membranes: caffeine > lidocaine > ketoprofen > ivermectin. For all drugs and for the virus model, the most effective formulation was the liposomal formulation, consisting of lipids found in the horny layer of the skin. The effect of the lanolin on the transmembrane water loss is not reflected on the drug permeation. Therefore, it is demonstrated the main role of ceramides in the barrier function for drugs and a virus model. Strengthening the barrier function of the mucosa promotes the prevention or reduction of the permeation of different actives, which could be to extrapolate to harmful actives like viruses, pollutants, toxins, contaminants, etc.
期刊介绍:
The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for the publication of novel, innovative and hypothesis-driven research from the areas of Pharmaceutics and Biopharmaceutics.
Topics covered include for example:
Design and development of drug delivery systems for pharmaceuticals and biopharmaceuticals (small molecules, proteins, nucleic acids)
Aspects of manufacturing process design
Biomedical aspects of drug product design
Strategies and formulations for controlled drug transport across biological barriers
Physicochemical aspects of drug product development
Novel excipients for drug product design
Drug delivery and controlled release systems for systemic and local applications
Nanomaterials for therapeutic and diagnostic purposes
Advanced therapy medicinal products
Medical devices supporting a distinct pharmacological effect.