Bess Frost, James B. Rowe, Rufus O. Akinyemi, Jose F. Abisambra, Nicholas J. Ashton, Matthias Brendel, Luc Buée, David Butler, Maria C. Carrillo, Peter Chung, Claire D. Clelland, Sarah L. DeVos, Kristophe Diaz, Rebecca M. Edelmayer, Fanny M. Elahi, Ratnavalli Ellajosyula, Colin Ewen, Igor Camargo Fontana, Marie-Christine Galas, Oskar Hansson, Günter Höglinger, Kanta Horie, Agustín Ibanez, Linde Jacobs, Mahmoud B. Maina, Maura Malpetti, Eric McDade, Will McEwan, Laia Montoliu-Gaya, Catherine J. Mummery, Miranda E. Orr, Jonathan D. Rohrer, Amy Rommel, Carlos Sastre, Tara L. Spires-Jones, Boon Lead Tee, Tim J. Viney, Jamie M. Walker, Susanne Wegmann, Kristin Wildsmith, Ravi Yadav, Simin Mahinrad, Claire Sexton
{"title":"对牛头病变的病理生理学，生物标志物和治疗方法的见解：Tau2024全球会议记录","authors":"Bess Frost, James B. Rowe, Rufus O. Akinyemi, Jose F. Abisambra, Nicholas J. Ashton, Matthias Brendel, Luc Buée, David Butler, Maria C. Carrillo, Peter Chung, Claire D. Clelland, Sarah L. DeVos, Kristophe Diaz, Rebecca M. Edelmayer, Fanny M. Elahi, Ratnavalli Ellajosyula, Colin Ewen, Igor Camargo Fontana, Marie-Christine Galas, Oskar Hansson, Günter Höglinger, Kanta Horie, Agustín Ibanez, Linde Jacobs, Mahmoud B. Maina, Maura Malpetti, Eric McDade, Will McEwan, Laia Montoliu-Gaya, Catherine J. Mummery, Miranda E. Orr, Jonathan D. Rohrer, Amy Rommel, Carlos Sastre, Tara L. Spires-Jones, Boon Lead Tee, Tim J. Viney, Jamie M. Walker, Susanne Wegmann, Kristin Wildsmith, Ravi Yadav, Simin Mahinrad, Claire Sexton","doi":"10.1002/alz.70078","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <p>Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the Alzheimer's Association, CurePSP, and Rainwater Charitable Foundation, showcased these efforts by bringing together researchers and experts worldwide to discuss the latest advancements in tau research. The conference aimed to attract talent and funding to study tauopathies, particularly among early-career researchers, and to foster interdisciplinary alignment and collaboration around challenges in tau research. In this manuscript, we summarize proceedings of the Tau2024 Global Conference, covering a wide range of topics, including lived experiences of individuals with genetic forms of tauopathies, global perspectives on tauopathies, and molecular mechanisms, brain microenvironments, biomarker developments, clinical trials, and therapeutic approaches to tauopathies. Through international, collaborative efforts, innovative research, and a commitment to inclusivity, researchers worldwide have demonstrated transformative breakthroughs toward diagnosing, treating, and, ultimately, preventing tau-related diseases.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>The Tau2024 Global Conference presented updates and advances in tau research.</li>\n \n <li>Blood-based biomarkers offer specificity and longitudinal monitoring capabilities.</li>\n \n <li>There are a range of targetable mechanisms in the cascade of pathogenesis.</li>\n \n <li>International collaboration is vital to address disparities in tauopathies.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70078","citationCount":"0","resultStr":"{\"title\":\"Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference\",\"authors\":\"Bess Frost, James B. 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Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference
Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the Alzheimer's Association, CurePSP, and Rainwater Charitable Foundation, showcased these efforts by bringing together researchers and experts worldwide to discuss the latest advancements in tau research. The conference aimed to attract talent and funding to study tauopathies, particularly among early-career researchers, and to foster interdisciplinary alignment and collaboration around challenges in tau research. In this manuscript, we summarize proceedings of the Tau2024 Global Conference, covering a wide range of topics, including lived experiences of individuals with genetic forms of tauopathies, global perspectives on tauopathies, and molecular mechanisms, brain microenvironments, biomarker developments, clinical trials, and therapeutic approaches to tauopathies. Through international, collaborative efforts, innovative research, and a commitment to inclusivity, researchers worldwide have demonstrated transformative breakthroughs toward diagnosing, treating, and, ultimately, preventing tau-related diseases.
Highlights
The Tau2024 Global Conference presented updates and advances in tau research.
Blood-based biomarkers offer specificity and longitudinal monitoring capabilities.
There are a range of targetable mechanisms in the cascade of pathogenesis.
International collaboration is vital to address disparities in tauopathies.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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