基于rna的生物催化剂在精准医学中的挑战与展望

IF 42.8 1区化学 Q1 CHEMISTRY, PHYSICAL

Nature Catalysis Pub Date : 2025-05-28 DOI:10.1038/s41929-025-01337-2

Charles H. Jones, Mikael Dolsten

引用次数: 0

摘要

基于rna的生物催化剂，包括核酶和CRISPR-Cas系统，有望通过精确的核酸操作实现基因转化治疗。这篇评论强调了关键的机制见解、治疗应用和临床翻译的挑战，提供了个性化医疗的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Challenges and prospects in precision medicine with RNA-based biocatalysts

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Challenges and prospects in precision medicine with RNA-based biocatalysts

RNA-based biocatalysts, including ribozymes and CRISPR–Cas systems, promise transformative gene therapies through precise nucleic acid manipulation. This Comment highlights the key mechanistic insights, therapeutic applications and challenges for clinical translation, offering the prospect of personalized medicine.

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来源期刊

Nature Catalysis Chemical Engineering-Bioengineering

CiteScore

52.10

自引率

1.10%

发文量

140

期刊介绍： Nature Catalysis serves as a platform for researchers across chemistry and related fields, focusing on homogeneous catalysis, heterogeneous catalysis, and biocatalysts, encompassing both fundamental and applied studies. With a particular emphasis on advancing sustainable industries and processes, the journal provides comprehensive coverage of catalysis research, appealing to scientists, engineers, and researchers in academia and industry. Maintaining the high standards of the Nature brand, Nature Catalysis boasts a dedicated team of professional editors, rigorous peer-review processes, and swift publication times, ensuring editorial independence and quality. The journal publishes work spanning heterogeneous catalysis, homogeneous catalysis, and biocatalysis, covering areas such as catalytic synthesis, mechanisms, characterization, computational studies, nanoparticle catalysis, electrocatalysis, photocatalysis, environmental catalysis, asymmetric catalysis, and various forms of organocatalysis.