道路交通噪声与脂肪组织库和肝脏脂肪含量的关系——来自德国国家队列（NAKO）的结果

IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-05-28 DOI:10.1016/j.envint.2025.109566

Fiona Niedermayer, Susanne Rospleszcz, Clara Matthiessen, Barbara Hoffmann, Sophia Stoecklein, Tobias Haueise, Tobias Norajitra, Christopher L. Schlett, Johanna Nattenmüller, Fabian Bamberg, Jürgen Machann, Matthias Günther, Jochen Hirsch, Rajini Nagrani, Henry Völzke, Claudia Meinke-Franze, Norbert Hosten, Tobias Nonnenmacher, Bettina Katalin Budai, Viktoria Palm, Annette Peters

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引用次数: 0

摘要

交通噪音暴露是心血管疾病的既定环境危险因素，但人们对其与早期肥胖相关的风险标志物（如脂肪组织（AT）和肝脏脂肪）之间的关系知之甚少。因此，我们旨在通过全身磁共振成像（MRI）评估长期道路交通噪声暴露与AT仓库测量的关系。我们分析了2014年至2016年间接受MRI检查的11,343名基于人群的德国国家队列（NAKO）参与者的横断面数据，将内脏（VAT）、皮下腹腔（SCAAT）、皮下胸腔（SCTAT）和肝脏脂肪含量作为结果。使用2017年的年度道路交通噪声（Lden）数据（来源：中央EIONET数据库）来计算参与者居住地10米和100米缓冲区内连续尺度上的加权平均噪声水平。在11101名具有完整结局数据的参与者中，48.7 %为女性，平均年龄为51.9 岁。较高的年Lden与男性AT库和肝脏脂肪含量增加有关(例如，VAT: 1.72 %-变化[95 ]%置信区间：[0.14 %；3.30 %);scat: 2.18 %-change[0.43 %；3.93 %]，肝脏脂肪含量：3.57 %-变化[1.41 %]；5.78 %]每10 dB（A)增加（10 m））和女性(例如，增值税：3.13 %-变化[1.09 %；5.18 %);scat: 2.38 %-change[0.55 %；4.20 %]，肝脏脂肪含量：3.08 %-变化[1.00 %；Lden（10 m）每10 dB(A)增加5.21 %])。在调整空气污染物和周围绿化后，所有结果都有很强的相关性，并且观察到肥胖和高血压对SCAAT、SCTAT和肝脏脂肪含量的影响。我们的研究结果表明，每年暴露于道路交通噪音与脂肪组织库和肝脏脂肪含量增加有关，因此为噪音与早期mri衍生的代谢健康标志物之间的横断面关联提供了新的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Associations of road traffic noise with adipose tissue depots and hepatic fat content – Results from the German National Cohort (NAKO)

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Associations of road traffic noise with adipose tissue depots and hepatic fat content – Results from the German National Cohort (NAKO)

Little is known about the relation between traffic noise exposure, an established environmental risk factor for cardiovascular disease, and early obesity-related risk markers such as adipose tissue (AT) and hepatic fat. Therefore, we aimed to assess associations of long-term road traffic noise exposure with AT depots measures from whole-body magnetic resonance imaging (MRI). We analyzed cross-sectional data from 11,343 participants from the population-based German National Cohort (NAKO) who underwent MRI examination between 2014 and 2016, considering visceral (VAT), subcutaneous abdominal (SCAAT), subcutaneous thoracic AT (SCTAT) and hepatic fat content as outcomes. Annual road traffic noise (L_den) data from the year 2017 (source: central EIONET data repository) was used to calculate weighted mean noise levels on a continuous scale within 10 and 100-meter buffers of participants’ residencies. Among 11,101 participants with complete outcome data, 48.7 % were women, and the mean age was 51.9 years. Higher annual L_den was associated with increased AT depots and hepatic fat content in men (e.g., VAT: 1.72 %-change [95 % confidence interval: [0.14 %; 3.30 %]; SCAAT: 2.18 %-change [0.43 %; 3.93 %], hepatic fat content: 3.57 %-change [1.41 %; 5.78 %] per 10 dB(A) increase in L_den (10 m)) and women (e.g., VAT: 3.13 %-change [1.09 %; 5.18 %]; SCAAT: 2.38 %-change [0.55 %; 4.20 %], hepatic fat content: 3.08 %-change [1.00 %; 5.21 %] per 10 dB(A) increase in L_den (10 m)). Associations were robust with all outcomes after adjusting for air pollutants and surrounding greenness, and effect modification by obesity and hypertension was observed for SCAAT, SCTAT and hepatic fat content. Our findings indicate that annual exposure to road traffic noise is associated with increased adipose tissue depots and hepatic fat content, and thus present novel evidence for the cross-sectional association between noise and early MRI-derived metabolic health markers.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.