衰老与免疫：古老的探戈

IF 7.7 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2025-05-28 DOI:10.1101/gad.352644.125

Inés Fernández Maestre, Alexander S. Harris, Corina Amor

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引用次数: 0

摘要

全球人口老龄化的加剧以及随后与年龄有关的疾病患病率的增加突出了了解衰老生物学的必要性。机体衰老的一个关键因素是免疫系统，它具有广泛的全身性影响。一方面，免疫老化涉及造血干细胞的下降和先天免疫和适应性免疫功能和组成的显著改变。另一方面，衰老的免疫系统有助于慢性炎症和破坏组织稳态，从而推动全身衰老过程。在这篇综述中，我们研究了衰老和免疫系统之间的密切相互作用，并讨论了旨在调节免疫功能以减轻年龄相关病理的新兴治疗策略。

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Aging and immunity: the age-old tango

The rising global demographic aging and the subsequent increase in the prevalence of age-related diseases highlight the need to understand aging biology. A key player in organismal aging is the immune system, which has broad systemic effects. On the one hand, immune aging involves the decline of hematopoietic stem cells and significant alterations in the functionality and composition of both innate and adaptive immunity. On the other hand, the aged immune system contributes to chronic inflammation and disrupted tissue homeostasis, thereby driving systemic aging processes. In this review, we examine the close interaction between aging and the immune system and discuss emerging therapeutic strategies aimed at modulating immune function to mitigate age-related pathologies.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).