肾上腺疾病的病理生理学和骨健康评价。

IF 2.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Endocrine Pub Date : 2025-08-01 Epub Date: 2025-05-28 DOI:10.1007/s12020-025-04260-5
M M Uygur, L di Filippo, S Frara, S Menotti, A Giustina
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引用次数: 0

摘要

肾上腺疾病与骨质减少/骨质疏松和脆性骨折的风险增加有关。虽然双能x线吸收仪仍然是评估骨密度的金标准,但其在准确预测椎体骨折方面的局限性强调了补充诊断工具的必要性,特别是在肾上腺疾病的背景下。椎体骨折通常无症状,如果没有针对性的评估,如形态计量学评估,可能无法发现。结合先进的诊断工具,如骨小梁评分,来评估肾上腺疾病相关的骨骼易碎性,可以增强对高危患者的识别,并支持量身定制的治疗策略。这篇综述从病理生理、临床和诊断角度探讨了骨骼脆弱性,并为医生提供了肾上腺疾病管理的指导,以改善骨骼健康结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathophysiology and evaluation of bone health in adrenal diseases.

Adrenal diseases are associated with an increased risk of osteopenia/osteoporosis and fragility fractures. Although dual-energy X-ray absorptiometry remains the gold standard for assessing bone mineral density, its limitations in accurately predicting vertebral fractures underscore the need for complementary diagnostic tools, particularly in the context of adrenal disorders. Vertebral fractures, often asymptomatic, may go undetected without targeted assessments such as morphometric evaluation. Incorporating advanced diagnostic tools, such as the trabecular bone score, into the evaluation of adrenal disorder-related skeletal fragility may enhance the identification of high-risk patients and support tailored therapeutic strategies. This review explores skeletal fragility from pathophysiological, clinical, and diagnostic perspectives and provides guidance to physicians for the management of adrenal disorders to improve bone health outcomes.

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来源期刊
Endocrine
Endocrine ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
5.40%
发文量
295
审稿时长
1.5 months
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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