间充质干细胞/基质细胞来源的外泌体:炎症性肠病的可能治疗机制

IF 3.4 3区 生物学 Q3 CELL BIOLOGY
Zekun Li, Luyun Liu, Yuhui Sun, Xinjuan Liu, Ping Zhang, Yue Wang, Gang Ding
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引用次数: 0

摘要

炎症性肠病(IBD)是一种在遗传易感个体中由免疫系统功能障碍引起的胃肠道慢性炎症性疾病。由于目前的药物和手术治疗仍然不理想,越来越多的人关注来自间充质干细胞/基质细胞(MSCs)的外泌体作为替代治疗方法。骨髓间充质干细胞是一种多能基质细胞,可以从骨髓、脂肪、脐带和牙周韧带等多种人体组织中分离出来。外泌体是细胞来源的膜结合囊泡,包裹rna、蛋白质、生长因子和细胞因子。先前的研究表明,MSCs的抗炎、免疫调节和再生作用主要是由MSCs衍生的外泌体(MSC-Exos)介导的。因此,本综述概述了MSC-Exos在IBD治疗中的分子机制,以支持MSC-Exos作为治疗策略的未来发展,从而为MSC-Exos在IBD治疗中的临床应用提供新的观察结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mesenchymal stem/stromal cells-derived exosomes: possible therapeutic mechanism in inflammatory bowel disease.

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract caused by dysfunction of the immune system in genetically susceptible individuals. As current pharmacologic and surgical treatments remain suboptimal, increasing attention has been directed toward exosomes derived from mesenchymal stem/stromal cells (MSCs) as alternative therapeutic approaches. MSCs are multipotent stromal cells that can be isolated from various human tissues such as bone marrow, adipose, umbilical cord and periodontal ligament. Exosomes are cell-derived membrane-bound vesicles enclosing RNAs, proteins, growth factors, and cytokines. Previous studies indicate that the anti-inflammatory, immunomodulatory, and regenerative effects of MSCs are largely mediated by MSC-derived exosomes (MSC-Exos). Therefore, this review outlines current insights into the molecular mechanisms of MSC-Exos in IBD treatment to support the future development of MSC-Exos as a therapeutic strategy, thus providing novel observations into the clinical applications of MSC-Exos in IBD management.

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来源期刊
Human Cell
Human Cell CELL BIOLOGY-
CiteScore
5.90
自引率
2.30%
发文量
176
审稿时长
4.5 months
期刊介绍: Human Cell is the official English-language journal of the Japan Human Cell Society. The journal serves as a forum for international research on all aspects of the human cell, encompassing not only cell biology but also pathology, cytology, and oncology, including clinical oncology. Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models with implications for human diseases are covered as well. Submissions in any of the following categories will be considered: Research Articles, Cell Lines, Rapid Communications, Reviews, and Letters to the Editor. A brief clinical case report focusing on cellular responses to pathological insults in human studies may also be submitted as a Letter to the Editor in a concise and short format. Not only basic scientists but also gynecologists, oncologists, and other clinical scientists are welcome to submit work expressing new ideas or research using human cells.
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