鼻腔优势增强了鼻内催产素的抗焦虑作用。

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Nikita Catalina Julius, Dasha Nicholls, Joseph Nowell, Victoria Burmester
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引用次数: 0

摘要

鼻循环是左右鼻孔气流交替变化的一种现象。在鼻孔充血或显性状态时,对侧鼻孔充血或非显性。鼻内催产素可引起抗焦虑作用。到目前为止,还没有研究调查催产素的效果是否存在最佳的鼻腔途径。这项探索性研究包括44名年龄在16至17岁的女性青少年,研究鼻腔优势对鼻内催产素释放的影响。我们发现,与安慰剂相比,鼻内催产素显著减轻了压力(p = 0.012, ηp2 = 0.145),当催产素被输送到优势鼻孔而不是非优势鼻孔时,压力减轻的效果更大(p = 0.034, ηp2 = 0.113)。我们假设催产素的施用可以减轻压力,并且在焦虑缓解的情况下,当给药到主导鼻孔时是最有效的。进一步研究其他鼻内精神药物是否具有鼻孔特异性作用可能有利于临床实践。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nasal dominance potentiates intranasal oxytocin's anxiolytic effects.

Nasal dominance potentiates intranasal oxytocin's anxiolytic effects.

Nasal dominance potentiates intranasal oxytocin's anxiolytic effects.

Nasal dominance potentiates intranasal oxytocin's anxiolytic effects.

The nasal cycle is a phenomenon whereby alterations in airflow alternate between left and right nostrils. During a nostril's decongested - or dominant - state, the contralateral nostril is congested, or non-dominant. Intranasal oxytocin may elicit anxiolytic effects. To date, no study has investigated whether there is an optimal nasal pathway for oxytocin's effects. Forty-four female adolescents aged 16 to 17 years were included in this exploratory study investigating effects of nasal dominance on intranasal oxytocin delivery. We show that intranasal oxytocin significantly reduces stress relative to placebo (p = 0.012, ηp2 = 0.145) and greater stress reduction occurs when oxytocin is delivered to the dominant, rather than non-dominant, nostril (p = 0.034, ηp2 = 0.113). We postulate that oxytocin administration may reduce stress and be most effective in the context of anxiolysis when administered to the dominant nostril. Further research investigating whether other intranasal psychotropic drugs have nostril-specific effects might benefit clinical practice.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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