{"title":"特发性中枢性性早熟女孩的脑功能连接和拓扑结构改变：基于静息状态fMRI的图论分析。","authors":"Lu Tian, Yan Zeng, Helin Zheng, Jinhua Cai","doi":"10.3390/children12050565","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate changes in brain functional connectivity (FC) and topological structure in girls with idiopathic central precocious puberty (ICPP) using complex network theory analysis.</p><p><strong>Methods: </strong>Resting-state fMRI data from 53 ICPP girls (ages 6-8) and 51 controls were analysed. Graph theory was used to construct whole-brain functional networks, identify topological differences, and assess the relationship between sex hormone levels and network properties in regions with group differences.</p><p><strong>Results: </strong>RS-FC analysis revealed reduced connectivity in cognitive and emotional regulation regions in the ICPP group (<i>p</i> < 0.05), but enhanced connectivity in emotional perception and self-regulation areas, such as the amygdala and insula (<i>p</i> < 0.05), suggesting a compensatory mechanism. Graph theory showed that ICPP girls' brain networks maintained small-world properties (γ > 1, λ ≈ 1, σ > 1). Local topological changes included decreased clustering and node efficiency in cognitive and emotional regulation regions, like the superior frontal gyrus and praecuneus (<i>p</i> < 0.05), while emotional regulation regions (amygdala, insula) showed increased clustering and node efficiency (<i>p</i> < 0.05), indicating compensation.</p><p><strong>Conclusions: </strong>This study highlights compensatory mechanisms in emotional regulation that may offset impairments in cognitive regions, offering new insights into ICPP's neural mechanisms.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 5","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110184/pdf/","citationCount":"0","resultStr":"{\"title\":\"Altered Brain Functional Connectivity and Topological Structural in Girls with Idiopathic Central Precocious Puberty: A Graph Theory Analysis Based on Resting-State fMRI.\",\"authors\":\"Lu Tian, Yan Zeng, Helin Zheng, Jinhua Cai\",\"doi\":\"10.3390/children12050565\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aimed to investigate changes in brain functional connectivity (FC) and topological structure in girls with idiopathic central precocious puberty (ICPP) using complex network theory analysis.</p><p><strong>Methods: </strong>Resting-state fMRI data from 53 ICPP girls (ages 6-8) and 51 controls were analysed. Graph theory was used to construct whole-brain functional networks, identify topological differences, and assess the relationship between sex hormone levels and network properties in regions with group differences.</p><p><strong>Results: </strong>RS-FC analysis revealed reduced connectivity in cognitive and emotional regulation regions in the ICPP group (<i>p</i> < 0.05), but enhanced connectivity in emotional perception and self-regulation areas, such as the amygdala and insula (<i>p</i> < 0.05), suggesting a compensatory mechanism. Graph theory showed that ICPP girls' brain networks maintained small-world properties (γ > 1, λ ≈ 1, σ > 1). Local topological changes included decreased clustering and node efficiency in cognitive and emotional regulation regions, like the superior frontal gyrus and praecuneus (<i>p</i> < 0.05), while emotional regulation regions (amygdala, insula) showed increased clustering and node efficiency (<i>p</i> < 0.05), indicating compensation.</p><p><strong>Conclusions: </strong>This study highlights compensatory mechanisms in emotional regulation that may offset impairments in cognitive regions, offering new insights into ICPP's neural mechanisms.</p>\",\"PeriodicalId\":48588,\"journal\":{\"name\":\"Children-Basel\",\"volume\":\"12 5\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-04-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110184/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Children-Basel\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/children12050565\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Children-Basel","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/children12050565","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
Altered Brain Functional Connectivity and Topological Structural in Girls with Idiopathic Central Precocious Puberty: A Graph Theory Analysis Based on Resting-State fMRI.
Objectives: This study aimed to investigate changes in brain functional connectivity (FC) and topological structure in girls with idiopathic central precocious puberty (ICPP) using complex network theory analysis.
Methods: Resting-state fMRI data from 53 ICPP girls (ages 6-8) and 51 controls were analysed. Graph theory was used to construct whole-brain functional networks, identify topological differences, and assess the relationship between sex hormone levels and network properties in regions with group differences.
Results: RS-FC analysis revealed reduced connectivity in cognitive and emotional regulation regions in the ICPP group (p < 0.05), but enhanced connectivity in emotional perception and self-regulation areas, such as the amygdala and insula (p < 0.05), suggesting a compensatory mechanism. Graph theory showed that ICPP girls' brain networks maintained small-world properties (γ > 1, λ ≈ 1, σ > 1). Local topological changes included decreased clustering and node efficiency in cognitive and emotional regulation regions, like the superior frontal gyrus and praecuneus (p < 0.05), while emotional regulation regions (amygdala, insula) showed increased clustering and node efficiency (p < 0.05), indicating compensation.
Conclusions: This study highlights compensatory mechanisms in emotional regulation that may offset impairments in cognitive regions, offering new insights into ICPP's neural mechanisms.
期刊介绍：
Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries.
The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
