Majd Bairkdar, Karina Patasova, Pontus Andell, Marie Holmqvist
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We also studied the outcomes of AMI in SSc compared with the matched comparators.</p><p><strong>Results: </strong>We identified 1579 patients and 16 064 comparators. The incidence rate of AMI was 75.2 (95% CI 58.8-94.6) per 10 000 person-years in patients with SSc and 37.5 (95% CI 34.0-41.3) in the comparators, median follow-up was 5.2 and 6.3 years, respectively. The adjusted hazard ratio (HR) was highest during the first year after SSc diagnosis (HR 3.1, 95% CI 2.0-4.6). In patients with SSc, the risk of AMI increased more rapidly with increasing age compared with the comparators. AMI in SSc was associated with higher risk of mortality (HR 2.7, 95% CI 1.6-4.4) but not 30-day readmission (HR 1.3, 95% CI 0.7-2.0) compared with the comparators.</p><p><strong>Conclusion: </strong>In line with previous studies, SSc is associated with a 2-fold increase in AMI incidence compared with the general population.</p>","PeriodicalId":21350,"journal":{"name":"Rheumatology Advances in Practice","volume":"9 2","pages":"rkaf054"},"PeriodicalIF":2.1000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106857/pdf/","citationCount":"0","resultStr":"{\"title\":\"Increased risk of acute myocardial infarction in Swedish patients with systemic sclerosis: a population-based study.\",\"authors\":\"Majd Bairkdar, Karina Patasova, Pontus Andell, Marie Holmqvist\",\"doi\":\"10.1093/rap/rkaf054\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To study the risk of acute myocardial infarction (AMI) in patients with SSc in a population-based cohort.</p><p><strong>Methods: </strong>Using nationwide Swedish registers, we identified patients with incident SSc 2004-19 and age- and sex-matched comparators from the general population (1:10). Our primary outcome was incident AMI or death from incident AMI. We started follow-up from SSc diagnosis until the primary outcome, death from other cause than AMI, emigration or study end (31 December 2019). We estimated crude AMI incidence rate. We used flexible parametric models to explore the relative risk of AMI over time since diagnosis. We also used age as time scale to explore how AMI risk changes over increasing age. We also studied the outcomes of AMI in SSc compared with the matched comparators.</p><p><strong>Results: </strong>We identified 1579 patients and 16 064 comparators. The incidence rate of AMI was 75.2 (95% CI 58.8-94.6) per 10 000 person-years in patients with SSc and 37.5 (95% CI 34.0-41.3) in the comparators, median follow-up was 5.2 and 6.3 years, respectively. The adjusted hazard ratio (HR) was highest during the first year after SSc diagnosis (HR 3.1, 95% CI 2.0-4.6). In patients with SSc, the risk of AMI increased more rapidly with increasing age compared with the comparators. AMI in SSc was associated with higher risk of mortality (HR 2.7, 95% CI 1.6-4.4) but not 30-day readmission (HR 1.3, 95% CI 0.7-2.0) compared with the comparators.</p><p><strong>Conclusion: </strong>In line with previous studies, SSc is associated with a 2-fold increase in AMI incidence compared with the general population.</p>\",\"PeriodicalId\":21350,\"journal\":{\"name\":\"Rheumatology Advances in Practice\",\"volume\":\"9 2\",\"pages\":\"rkaf054\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-05-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106857/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Rheumatology Advances in Practice\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/rap/rkaf054\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rheumatology Advances in Practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/rap/rkaf054","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的:研究SSc患者急性心肌梗死(AMI)的风险。方法:使用瑞典全国范围的登记册,我们从普通人群中确定2004-19年SSc事件的患者和年龄和性别匹配的比较者(1:10)。我们的主要结局是急性心肌梗塞或因急性心肌梗塞而死亡。我们从SSc诊断开始随访,直到主要结局、AMI以外的其他原因死亡、移民或研究结束(2019年12月31日)。我们估计了AMI的粗发生率。我们使用灵活的参数模型来探讨自诊断以来AMI的相对风险。我们还使用年龄作为时间尺度来探索AMI风险如何随着年龄的增长而变化。我们还研究了与匹配比较者相比,SSc的AMI结果。结果:我们确定了1579名患者和16064名比较者。SSc患者的AMI发病率为每10000人年75.2例(95% CI 58.8-94.6),对照组为每10000人年37.5例(95% CI 34.0-41.3),中位随访时间分别为5.2年和6.3年。SSc诊断后的第一年校正风险比(HR)最高(HR 3.1, 95% CI 2.0-4.6)。在SSc患者中,与对照组相比,随着年龄的增长,AMI的风险增加得更快。与比较组相比,SSc的AMI与较高的死亡率相关(HR 2.7, 95% CI 1.6-4.4),但与30天再入院无关(HR 1.3, 95% CI 0.7-2.0)。结论:与以往的研究一致,与普通人群相比,SSc与AMI发生率增加2倍相关。
Increased risk of acute myocardial infarction in Swedish patients with systemic sclerosis: a population-based study.
Objectives: To study the risk of acute myocardial infarction (AMI) in patients with SSc in a population-based cohort.
Methods: Using nationwide Swedish registers, we identified patients with incident SSc 2004-19 and age- and sex-matched comparators from the general population (1:10). Our primary outcome was incident AMI or death from incident AMI. We started follow-up from SSc diagnosis until the primary outcome, death from other cause than AMI, emigration or study end (31 December 2019). We estimated crude AMI incidence rate. We used flexible parametric models to explore the relative risk of AMI over time since diagnosis. We also used age as time scale to explore how AMI risk changes over increasing age. We also studied the outcomes of AMI in SSc compared with the matched comparators.
Results: We identified 1579 patients and 16 064 comparators. The incidence rate of AMI was 75.2 (95% CI 58.8-94.6) per 10 000 person-years in patients with SSc and 37.5 (95% CI 34.0-41.3) in the comparators, median follow-up was 5.2 and 6.3 years, respectively. The adjusted hazard ratio (HR) was highest during the first year after SSc diagnosis (HR 3.1, 95% CI 2.0-4.6). In patients with SSc, the risk of AMI increased more rapidly with increasing age compared with the comparators. AMI in SSc was associated with higher risk of mortality (HR 2.7, 95% CI 1.6-4.4) but not 30-day readmission (HR 1.3, 95% CI 0.7-2.0) compared with the comparators.
Conclusion: In line with previous studies, SSc is associated with a 2-fold increase in AMI incidence compared with the general population.