利用全基因组序列数据对汉宇牛和安格斯牛的选择特征进行全基因组扫描。

IF 2.9 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

PLoS ONE Pub Date : 2025-05-27 eCollection Date: 2025-01-01 DOI:10.1371/journal.pone.0324034

Hyoun Ju Kim, Nasir Moghaddar, Sam Clark, Julius H J van der Werf, Sara de Las Heras-Saldana

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引用次数: 0

摘要

本研究利用406头肉牛（203头韩宇和203头安格斯）的全基因组序列数据，采用四种不同的方法检测选择特征；综合单倍型评分（his）、Rsb、XP-EHH和纯合子数（ROH）。基于Rsb和XP-EHH分析，安格斯犬和韩宇犬分别有36个和21个基因组区存在显著差异。在品种中，我们用ROH分析确定了108个区域（韩宇76个，安格斯32个），用iHS方法确定了331个区域（韩宇298个，安格斯33个）。与肉质性状相关的候选基因包括HSPA9和LPL，而与生长和肉量性状相关的候选基因包括ACTC1和TMEM68，在安格斯中被发现。该研究有助于了解这些品种的选择历史，并确定与这些品种的育种计划中选择的性状相关的基因组区域。

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Genome-wide scan for signatures of selection in Hanwoo and Angus cattle using whole-genome sequence data.

This study used whole-genome sequence data on 406 beef cattle (203 Hanwoo and 203 Angus) to detect signatures of selection using four different methods; integrated haplotype score (iHS), Rsb, XP-EHH, and runs of homozygosity (ROH). Based on Rsb and XP-EHH analysis, 36 and 21 genomic regions differed significantly between Angus and Hanwoo breeds. Within breeds, we identified 108 regions (76 in Hanwoo and 32 in Angus) with the ROH analysis and 331 regions with the iHS method (298 in Hanwoo and 33 in Angus). The candidate genes related to meat quality, such as HSPA9 and LPL, were found within Hanwoo, while genes associated with growth and meat quantity traits, including ACTC1 and TMEM68, were identified within Angus. This study can assist in understanding the selection history of these breeds and identifying the genomic regions associated with the traits selected for in the breeding programs for these cattle breeds.

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来源期刊

PLoS ONE 生物-生物学

CiteScore

6.20

自引率

5.40%

发文量

14242

审稿时长

3.7 months

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