PI3Kγ在肿瘤炎症中的作用：桥接免疫反应和癌症进展

IF 4.9 3区医学 Q2 IMMUNOLOGY

Immunology Pub Date : 2025-05-28 DOI:10.1111/imm.13959

Anghesom Ghebremedhin, Judith A Varner

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引用次数: 0

摘要

磷脂酰肌醇3-激酶γ (PI3Kγ)是一类PI3K家族成员，在调节肿瘤微环境中的炎症和免疫反应中起关键作用。新出现的证据表明，PI3Kγ促进髓细胞运输和转录，导致肿瘤进展和转移。这篇综述探讨了PI3Kγ在肿瘤相关炎症中的多方面作用，强调了它参与免疫细胞极化、细胞因子产生以及肿瘤细胞与周围基质环境之间的动态相互作用。我们还讨论了靶向PI3Kγ调节炎症和抑制肿瘤生长的潜在治疗意义。鉴于其在免疫反应和肿瘤进展中的关键作用，PI3Kγ代表了未来癌症治疗减少炎症驱动的肿瘤发生的有希望的靶点。

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PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression-A Mini-Review.

Phosphatidylinositol 3-kinase gamma (PI3Kγ), a class I PI3K family member, plays a critical role in modulating inflammation and immune responses within the tumour microenvironment. Emerging evidence suggests that PI3Kγ promotes myeloid cell trafficking and transcription, leading to tumour progression and metastasis. This review explores the multifaceted roles of PI3Kγ in tumour-associated inflammation, highlighting its involvement in immune cell polarisation, cytokine production, and the dynamic interaction between tumour cells and the surrounding stromal environment. We also discuss the potential therapeutic implications of targeting PI3Kγ to modulate inflammation and inhibit tumour growth. Given its pivotal role in immune response and tumour progression, PI3Kγ represents a promising target for future cancer therapies to reduce inflammation-driven tumorigenesis.

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来源期刊

Immunology 医学-免疫学

CiteScore

11.90

自引率

1.60%

发文量

175

审稿时长

4-8 weeks

期刊介绍： Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers. Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology. The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.