基于个体因素的西安市新冠肺炎疫情影响及病原疾病风险模拟模型研究

IF 4.6 2区 医学 Q2 IMMUNOLOGY
Frontiers in Cellular and Infection Microbiology Pub Date : 2025-05-13 eCollection Date: 2025-01-01 DOI:10.3389/fcimb.2025.1547601
Wen Dong, Henan Yao, Wei-Na Wang
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引用次数: 0

摘要

导言:自2019年底首次发现并报告COVID - 19大流行以来,该病毒已在全球迅速传播。这导致了感染人数的显著上升。即使到现在,人们仍然怀疑它是否已经完全消失。此外,在确保安全的同时恢复正常生活的问题仍然是全球公共卫生机构和人民迫切需要解决的一项重大挑战。方法:为了深入了解疫情的爆发和传播特点,及时制定预防措施,充分保障人类生命财产安全,本文提出了一种基于个体因素的agent模型。结果:该模型将发生特征性疾病暴发的西安市作为研究区域。仿真结果与官方记录基本一致,有效验证了模型的适用性、适应性和推广性。这种经过验证的能力能够准确预测流行病趋势并全面评估疾病风险。讨论:从2021年底到2022年初,采用一对一的人口模拟方法,模拟疫情影响和疾病风险。首先,利用研究区域的建筑统计数据,该模型重建了当地的真实地理环境。利用第七次全国人口普查的数据,它还复制了研究区域的人口特征。其次,该模型考虑了人口流动、接触者追踪、患者治疗和COVID - 19样流感症状的诊断负担。将流行病传播影响参数整合到模型框架中。最后,将模型的结果与官方数据进行比较以验证,并将其应用于假设的场景。它为政府主导的预防和控制措施的实施提供了科学的理论工具。此外,它有助于调整个人行为准则,促进更有效的流行病管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study on the impact of COVID-19 epidemic and agent disease risk simulation model based on individual factors in Xi'an City.

Introduction: Since the first discovery and reporting of the COVID - 19 pandemic towards the end of 2019, the virus has rapidly propagated across the world. This has led to a remarkable spike in the number of infections. Even now, doubt lingers over whether it has completely disappeared. Moreover, the issue of restoring normal life while ensuring safety continues to be a crucial challenge that public health agencies and people globally are eager to tackle.

Methods: To thoroughly understand the epidemic's outbreak and transmission traits and formulate timely prevention measures to fully safeguard human lives and property, this paper presents an agent - based model incorporating individual - level factors.

Results: The model designates Xi'an-where a characteristic disease outbreak occurred-as the research area. The simulation results demonstrate substantial consistency with official records, effectively validating the model's applicability, adaptability, and generalizability. This validated capacity enables accurate prediction of epidemic trends and comprehensive assessment of disease risks.

Discussion: From late 2021 to early 2022, it employs a one - to - one population simulation approach and simulates epidemic impacts and disease risks. Initially, using building statistical data in the study area, the model reconstructs the local real - world geographical environment. Leveraging data from the seventh national population census, it also replicates the study area's population characteristics. Next, the model takes into account population mobility, contact tracing, patient treatment, and the diagnostic burden of COVID - 19 - like influenza symptoms. It integrates epidemic transmission impact parameters into the model framework. Eventually, the model's results are compared with official data for validation, and it's applied to hypothetical scenarios. It provides scientific theoretical tools to support the implementation of government - driven prevention and control measures. Additionally, it facilitates the adjustment of individual behavioral guidelines, promoting more effective epidemic management.

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来源期刊
CiteScore
7.90
自引率
7.00%
发文量
1817
审稿时长
14 weeks
期刊介绍: Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.
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