{"title":"下颌骨导航辅助手术的患者特异性动态参考框架：一种新的无创技术方法。","authors":"Jinyang Wu, Lai Jiang, Yingqi Cheng, Wenbin Zhang, Jianfei Zhang, Xiaoyan Gao, Xiaofeng Xu, Shilei Zhang","doi":"10.3389/fbioe.2025.1577321","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Computer-assisted navigation has been established as a valuable tool in oral and craniomaxillofacial surgery. However, the steep learning curve associated with mandibular navigation surgery has hindered its widespread adoption. This study introduces a non-invasive, convenient, and accurate navigation method for mandibular surgery and evaluates its clinical effectiveness.</p><p><strong>Methods: </strong>A modified patient-specific dynamic reference frame (PS-DRF) was designed and fabricated based on the patient's lower jaw dental cast, integrating navigation technology with 3D printing. During surgery, the PS-DRF was securely affixed to the lower dentition, enabling automatic pair-point registration through fiducial localization via a navigation probe. The surgical procedure was conducted under real-time navigation guidance.</p><p><strong>Results: </strong>Preoperative registration and intraoperative navigation were successfully achieved in this case. The navigation-guided mandibular surgery was completed without complications. Postoperative superimposition of the simulated virtual model and the actual surgical outcome demonstrated high accuracy, with a deviation of less than 2 mm.</p><p><strong>Conclusion: </strong>The PS-DRF system offers a convenient, effective, and adaptable approach by integrating navigation technology with 3D printing. This method has the potential to simplify navigation-assisted mandibular surgery and facilitate the broader clinical implementation of computer-assisted navigation in maxillofacial procedures.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1577321"},"PeriodicalIF":4.3000,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106423/pdf/","citationCount":"0","resultStr":"{\"title\":\"Patient-specific dynamic reference frame for navigation-assisted surgery in mandible: a novel noninvasive technical method.\",\"authors\":\"Jinyang Wu, Lai Jiang, Yingqi Cheng, Wenbin Zhang, Jianfei Zhang, Xiaoyan Gao, Xiaofeng Xu, Shilei Zhang\",\"doi\":\"10.3389/fbioe.2025.1577321\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Computer-assisted navigation has been established as a valuable tool in oral and craniomaxillofacial surgery. However, the steep learning curve associated with mandibular navigation surgery has hindered its widespread adoption. This study introduces a non-invasive, convenient, and accurate navigation method for mandibular surgery and evaluates its clinical effectiveness.</p><p><strong>Methods: </strong>A modified patient-specific dynamic reference frame (PS-DRF) was designed and fabricated based on the patient's lower jaw dental cast, integrating navigation technology with 3D printing. During surgery, the PS-DRF was securely affixed to the lower dentition, enabling automatic pair-point registration through fiducial localization via a navigation probe. The surgical procedure was conducted under real-time navigation guidance.</p><p><strong>Results: </strong>Preoperative registration and intraoperative navigation were successfully achieved in this case. The navigation-guided mandibular surgery was completed without complications. Postoperative superimposition of the simulated virtual model and the actual surgical outcome demonstrated high accuracy, with a deviation of less than 2 mm.</p><p><strong>Conclusion: </strong>The PS-DRF system offers a convenient, effective, and adaptable approach by integrating navigation technology with 3D printing. This method has the potential to simplify navigation-assisted mandibular surgery and facilitate the broader clinical implementation of computer-assisted navigation in maxillofacial procedures.</p>\",\"PeriodicalId\":12444,\"journal\":{\"name\":\"Frontiers in Bioengineering and Biotechnology\",\"volume\":\"13 \",\"pages\":\"1577321\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-05-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106423/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Bioengineering and Biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.3389/fbioe.2025.1577321\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2025.1577321","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Patient-specific dynamic reference frame for navigation-assisted surgery in mandible: a novel noninvasive technical method.
Objectives: Computer-assisted navigation has been established as a valuable tool in oral and craniomaxillofacial surgery. However, the steep learning curve associated with mandibular navigation surgery has hindered its widespread adoption. This study introduces a non-invasive, convenient, and accurate navigation method for mandibular surgery and evaluates its clinical effectiveness.
Methods: A modified patient-specific dynamic reference frame (PS-DRF) was designed and fabricated based on the patient's lower jaw dental cast, integrating navigation technology with 3D printing. During surgery, the PS-DRF was securely affixed to the lower dentition, enabling automatic pair-point registration through fiducial localization via a navigation probe. The surgical procedure was conducted under real-time navigation guidance.
Results: Preoperative registration and intraoperative navigation were successfully achieved in this case. The navigation-guided mandibular surgery was completed without complications. Postoperative superimposition of the simulated virtual model and the actual surgical outcome demonstrated high accuracy, with a deviation of less than 2 mm.
Conclusion: The PS-DRF system offers a convenient, effective, and adaptable approach by integrating navigation technology with 3D printing. This method has the potential to simplify navigation-assisted mandibular surgery and facilitate the broader clinical implementation of computer-assisted navigation in maxillofacial procedures.
期刊介绍：
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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