{"title":"甲状腺激素受体接近40岁生日。","authors":"Frédéric Flamant","doi":"10.1210/endocr/bqaf094","DOIUrl":null,"url":null,"abstract":"<p><p>Taking advantage of the approaching 40th birthday of seminal articles describing the cloning of the genes that encode the nuclear receptors of thyroid hormone, Endocrinology publishes a collection of review articles dedicated to these receptors. The collection highlights advances in understanding the structure, ligand interactions, and crosstalk with other signaling pathways. It reports ongoing research which continues to reveal the complexity and physiological relevance of TR functions in tissues. Despite progress, key questions remain about cell-specific gene regulation, negative feedback mechanisms, and TR involvement in cancer. The new collection of review articles published in Endocrinology represents a milestone in a long-term project which illustrates the diversity of information that TR-centered research brings to basic science. They also outline that there is plenty of room for new and exciting investigations.</p>","PeriodicalId":11819,"journal":{"name":"Endocrinology","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Thyroid hormone receptors approach their 40th birthday.\",\"authors\":\"Frédéric Flamant\",\"doi\":\"10.1210/endocr/bqaf094\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Taking advantage of the approaching 40th birthday of seminal articles describing the cloning of the genes that encode the nuclear receptors of thyroid hormone, Endocrinology publishes a collection of review articles dedicated to these receptors. The collection highlights advances in understanding the structure, ligand interactions, and crosstalk with other signaling pathways. It reports ongoing research which continues to reveal the complexity and physiological relevance of TR functions in tissues. Despite progress, key questions remain about cell-specific gene regulation, negative feedback mechanisms, and TR involvement in cancer. The new collection of review articles published in Endocrinology represents a milestone in a long-term project which illustrates the diversity of information that TR-centered research brings to basic science. They also outline that there is plenty of room for new and exciting investigations.</p>\",\"PeriodicalId\":11819,\"journal\":{\"name\":\"Endocrinology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrinology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1210/endocr/bqaf094\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1210/endocr/bqaf094","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Thyroid hormone receptors approach their 40th birthday.
Taking advantage of the approaching 40th birthday of seminal articles describing the cloning of the genes that encode the nuclear receptors of thyroid hormone, Endocrinology publishes a collection of review articles dedicated to these receptors. The collection highlights advances in understanding the structure, ligand interactions, and crosstalk with other signaling pathways. It reports ongoing research which continues to reveal the complexity and physiological relevance of TR functions in tissues. Despite progress, key questions remain about cell-specific gene regulation, negative feedback mechanisms, and TR involvement in cancer. The new collection of review articles published in Endocrinology represents a milestone in a long-term project which illustrates the diversity of information that TR-centered research brings to basic science. They also outline that there is plenty of room for new and exciting investigations.
期刊介绍：
The mission of Endocrinology is to be the authoritative source of emerging hormone science and to disseminate that new knowledge to scientists, clinicians, and the public in a way that will enable "hormone science to health." Endocrinology welcomes the submission of original research investigating endocrine systems and diseases at all levels of biological organization, incorporating molecular mechanistic studies, such as hormone-receptor interactions, in all areas of endocrinology, as well as cross-disciplinary and integrative studies. The editors of Endocrinology encourage the submission of research in emerging areas not traditionally recognized as endocrinology or metabolism in addition to the following traditionally recognized fields: Adrenal; Bone Health and Osteoporosis; Cardiovascular Endocrinology; Diabetes; Endocrine-Disrupting Chemicals; Endocrine Neoplasia and Cancer; Growth; Neuroendocrinology; Nuclear Receptors and Their Ligands; Obesity; Reproductive Endocrinology; Signaling Pathways; and Thyroid.
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