Machine learning decision support model construction for craniotomy approach of pineal region tumors based on MRI images.

Background: Pineal region tumors (PRTs) are rare but deep-seated brain tumors, and complete surgical resection is crucial for effective tumor treatment. The choice of surgical approach is often challenging due to the low incidence and deep location. This study aims to combine machine learning and deep learning algorithms with pre-operative MRI images to build a model for PRTs surgical approaches recommendation, striving to model clinical experience for practical reference and education.

Methods: This study was a retrospective study which enrolled a total of 173 patients diagnosed with PRTs radiologically from our hospital. Three traditional surgical approaches of were recorded for prediction label. Clinical and VASARI related radiological information were selected for machine learning prediction model construction. And MRI images from axial, sagittal and coronal views of orientation were also used for deep learning craniotomy approach prediction model establishment and evaluation.

Results: 5 machine learning methods were applied to construct the predictive classifiers with the clinical and VASARI features and all methods could achieve area under the ROC (Receiver operating characteristic) curve (AUC) values over than 0.7. And also, 3 deep learning algorithms (ResNet-50, EfficientNetV2-m and ViT) were applied based on MRI images from different orientations. EfficientNetV2-m achieved the highest AUC value of 0.89, demonstrating a significant high performance of prediction. And class activation mapping was used to reveal that the tumor itself and its surrounding relations are crucial areas for model decision-making.

Conclusion: In our study, we used machine learning and deep learning to construct surgical approach recommendation models. Deep learning could achieve high performance of prediction and provide efficient and personalized decision support tools for PRTs surgical approach.

Clinical trial number: Not applicable.