益生菌作为抗肿瘤药物：来自女性肿瘤细胞培养研究的见解。

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2025-05-02 DOI:10.3390/biom15050657

Chiara Giorgi, Francesca Lombardi, Francesca Rosaria Augello, Ylli Alicka, Massimiliano Quintiliani, Skender Topi, Annamaria Cimini, Vanessa Castelli, Michele d'Angelo

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引用次数: 0

摘要

乳腺癌和卵巢癌是女性中最常见的癌症。癌细胞的特点是它们能够不断地循环和迁移，形成转移。一些益生菌菌株已显示出抗肿瘤作用。本研究通过Western blotting和抓伤试验分析参与细胞周期调节的蛋白（pP53、Cyclin D1、pERK1）、细胞存活（AKT）和细胞迁移（RhoA），检测益生菌对OVCAR-3和MDA-MB-231细胞系的影响。结果表明，处理后这些蛋白减少，细胞迁移速度减慢。这些发现表明，某些益生菌组合可以阻止细胞周期，促进细胞死亡，减少细胞迁移，可能与标准疗法一起成为有希望的候选药物。

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Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies.

Breast and ovarian cancers are among the most prevalent cancers in women. Cancerous cells are characterized by their ability to continuously cycle and migrate, forming metastases. Some probiotic strains have shown anti-tumorigenic effects. This study tested the impact of probiotics on OVCAR-3 and MDA-MB-231 cell lines by analyzing proteins involved in cell cycle regulation (pP53, Cyclin D1, pERK1), cell survival (AKT), and cell migration (RhoA) using Western blotting and scratch wound tests. Results indicated a reduction in these proteins and decreased cell migration velocity post-treatment. These findings suggest that certain probiotic combinations can arrest the cell cycle, promote cell death, and reduce cell migration, potentially serving as promising candidates alongside standard therapies.

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.