ABO血型对三级医院献血者输血传播感染流行率的影响

IF 1.9 4区 医学 Q2 PATHOLOGY
Chilota Chibuife Efobi, Emeka Stanley Obi, Oluwatobi Faniyi, Christian Elochukwu Offiah, Onyinyechi Victoria Okam, Onyinyechukwu Joyce Ndubuisi, Jonathan Izuchukwu Obidiegwu, Favour Chinonso Emezue, Okechukwu Elijah Umeh
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引用次数: 0

摘要

目的:输血传播感染是输血的严重并发症。设计一种检测高危献血者的方法可能对尼日利亚等低收入和中等收入国家有益。我们试图确定ABO血型对输血传播感染流行率的影响。方法:在尼日利亚Chukwuemeka Odumegwu Ojukwu大学教学医院血库使用献血者数据进行回顾性观察研究。检索到的捐赠者信息包括性别;血型;艾滋病毒、乙型肝炎表面抗原(HBsAg)、丙型肝炎病毒(HCV)和性病研究实验室筛查结果。使用Microsoft Excel对数据进行整理,使用R 4.3.2版本(R Foundation for Statistical Computing)进行数据分析。P结果:共审阅了2356份供体记录;这些捐赠者大多数是男性。研究人群中HIV、HBsAg、HCV和性病的患病率分别为0.5%、3.3%、1.6%和0.6%。B血型献血者感染HCV的风险可能增加(P结论:B血型献血者感染HCV的风险高于其他献血者。这一发现可以为供体选择和筛选提供更多的见解。需要更广泛的进一步研究来验证我们的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The impact of ABO blood group on the prevalence of transfusion-transmitted infections among blood donors in a tertiary-care hospital.

Objectives: Transfusion-transmitted infections are a serious complication of blood transfusion. Devising a means of detecting at-risk blood donors may be beneficial in low- and middle-income countries such as Nigeria. We sought to determine the impact of ABO blood group on the prevalence of transfusion transmitted infections.

Methods: A retrospective observational study was carried out at the blood bank of Chukwuemeka Odumegwu Ojukwu University Teaching Hospital in Nigeria using data from blood donors. Information retrieved about donors included sex; blood group; and results of HIV, hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), and Venereal Disease Research Laboratory screening results. Microsoft Excel was used to sort the data and, the data analysis was conducted using R, version 4.3.2 (R Foundation for Statistical Computing). P < .05 was considered statistically significant.

Results: A total of 2356 donor records were reviewed; the majority of these donors were male. The prevalence of HIV, HBsAg, HCV, and venereal diseases in the study population was 0.5%, 3.3%, 1.6%, and 0.6%, respectively. There was a possible increased risk of HCV among blood group B donors (P < .02799).

Conclusions: Blood group B donors were found to have a higher risk of contracting HCV infection than other donors. This finding could give more insights on donor selection and screening. Further studies that are more broadly based are required to validate our findings.

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来源期刊
CiteScore
7.70
自引率
2.90%
发文量
367
审稿时长
3-6 weeks
期刊介绍: The American Journal of Clinical Pathology (AJCP) is the official journal of the American Society for Clinical Pathology and the Academy of Clinical Laboratory Physicians and Scientists. It is a leading international journal for publication of articles concerning novel anatomic pathology and laboratory medicine observations on human disease. AJCP emphasizes articles that focus on the application of evolving technologies for the diagnosis and characterization of diseases and conditions, as well as those that have a direct link toward improving patient care.
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