手机使用特征、遗传易感性和帕金森病风险：一项前瞻性队列研究

IF 7.1 2区医学 Q1 GERIATRICS & GERONTOLOGY

Age and ageing Pub Date : 2025-05-03 DOI:10.1093/ageing/afaf143

Juanjuan Zhang, Junjie Zou, Yuerong He, Jiale Shen, Kunjuan Jing, Ruiqi An, Zhen Wang, Xiaoyan Yao, Chao Ren, Yang Xia

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引用次数: 0

摘要

我们利用英国生物银行的数据，调查了手机使用特征与帕金森病（PD）风险之间的关系，以及遗传易感性是否改变了这些关系。与每周使用手机少于5分钟的参与者相比，每周使用手机至少一小时的参与者患PD的风险更低（HR: 0.75, 95% CI: 0.65-0.87）。与手机使用时间≤1年的参与者相比，手机使用时间超过8年的长期用户的风险降低了18% (HR: 0.82, 95% CI: 0.68-1.00)，两年内手机使用频率增加的参与者的风险比没有改变的参与者低12% （HR: 0.88, 95% CI: 0.79-0.98）。手机使用特征与PD-PRS无交互作用。总的脑容量、灰质和白质与手机使用呈正相关，而白质高强度则呈负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mobile phone use characteristics, genetic predisposition and the risk of Parkinson's disease: a prospective cohort study.

We investigated the association between mobile phone use characteristics and Parkinson's disease (PD) risk and whether genetic predisposition modified these associations, utilising data from the UK Biobank. Participants using mobile phones for at least one hour weekly had a lower risk of PD compared to those using less than five minutes weekly (HR: 0.75, 95% CI: 0.65-0.87). Long-term users of mobile phones over eight years had an 18% reduced risk compared to participants with a length of mobile phone use ≤1 year (HR: 0.82, 95% CI: 0.68-1.00), and increased frequency of mobile phone use over two years was associated with a 12% lower risk than those who did not change (HR: 0.88, 95% CI: 0.79-0.98). No interaction between mobile phone use characteristics and PD-PRS was detected. Total brain volume, grey matter and white matter were positively associated with mobile phone use, while white matter hyperintensity was negatively associated.

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来源期刊

Age and ageing 医学-老年医学

CiteScore

9.20

自引率

6.00%

发文量

796

审稿时长

4-8 weeks

期刊介绍： Age and Ageing is an international journal publishing refereed original articles and commissioned reviews on geriatric medicine and gerontology. Its range includes research on ageing and clinical, epidemiological, and psychological aspects of later life.