十通酸催化α-C(sp3)-H酰胺与对醌类化合物的功能化。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-05-20 DOI:10.1039/d5ob00619h

Lin He , Hongyu Chen , Dan Yang , Liyuan Cheng , Xile Jiang , Mingsong Shi

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引用次数: 0

摘要

描述了一种有效的光催化合成n -甲基甲酰胺修饰的二芳基甲烷支架的策略，该策略涉及通过四丁基十钨酸铵催化的氢原子转移过程将对醌甲基1,6偶联加成到酰胺上。该方案具有条件温和，操作简便，收率优良（高达92%），广泛兼容各种官能团的特点。

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Decatungstate-catalyzed α-C(sp3)–H functionalization of amides with para-quinone methides†

An efficient photocatalytic strategy for the synthesis of N-methylformamide-modified diarylmethane scaffolds that involves the 1,6-conjugate addition of a para-quinone methide to amides via a tetrabutylammonium-decatungstate-catalyzed hydrogen atom transfer process has been described. This protocol features mild conditions, operational ease, and good-to-excellent yields (up to 92%), and is broadly compatible with a variety of functional groups.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.