对常规治疗无反应的子宫内膜异位症患者进行多模式监督治疗运动后疲劳、健康相关体能、睡眠质量、心理健康、胃肠道疾病和性功能的变化：一项随机对照试验的二次分析

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-05-24 DOI:10.1016/j.ejogrb.2025.114083

María del Mar Salinas-Asensio , Francisco Álvarez-Salvago , Antonio Mundo-López , Olga Ocón-Hernández , Mario Lozano-Lozano , María López-Garzón , Paula Postigo-Martín , Manuel Arroyo-Morales , Ángel Rodríguez-Ruiz , Carolina Fernández-Lao , Francisco Artacho-Cordón

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引用次数: 0

摘要

目的探讨“Physio-EndEA”（一项为期9周的多模式监督运动干预）对常规治疗无效的子宫内膜异位症患者的疲劳、健康相关体质、睡眠质量、心理健康、胃肠道不适和性功能的影响。方法31例患者随机分为“Physio-EndEA”组（n = 16）和对照组（n = 15）。使用Piper疲劳量表（PFS）对主要终点疲劳进行评估。次要结局包括健康相关体质[腰力量（背部测功仪）、腰柔韧性（Schöber测试）、身体平衡（火烈鸟测试）和心肺健康（6分钟步行测试，6MWT）]、睡眠质量（匹兹堡睡眠质量指数，PSQI）、焦虑和抑郁（医院焦虑抑郁量表，HADS）、消化不适（胃肠道生活质量指数，GIQLI）和性功能（女性性功能指数，FSFI）。在基线、干预后和一年时测量结果。统计（组间协方差分析）和临床效果分析意向治疗。该研究已在ClinicalTrials.gov注册，编号NCT03979183。结果干预后及干预后1年，“Physio-EndEA”组患者的疲劳度较对照组有明显改善，且有较大的尺寸效应(d >；0.80)。干预后，干预组在腰椎力量、心肺健康、焦虑、抑郁和消化系统疾病评分方面也有改善。在1年的随访中，心肺健康、焦虑和消化系统疾病均得到改善。结论：为期9周的多模式运动治疗方案可有效改善多种子宫内膜异位症相关损伤，提示“Physio-EndEA”是一种有希望的策略，可减轻对常规治疗无反应的子宫内膜异位症患者的症状负担。

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Changes in fatigue, health-related fitness, sleep quality, mental health, gastrointestinal complaints and sexual function after a multimodal supervised therapeutic exercise program in women with endometriosis unresponsive to conventional therapy: a secondary analysis of a randomized controlled trial

Objective

To explore the impact of ‘Physio-EndEA’, a multimodal 9-week supervised exercise intervention, on fatigue, health-related physical fitness, sleep quality, mental health, gastrointestinal complaints, and sexual function in women with endometriosis unresponsive to conventional therapy.

Methods

This randomized controlled trial included 31 patients randomly allocated to the ‘Physio-EndEA’ group (n = 16) or the control group (n = 15). The primary outcome, fatigue, was evaluated using the Piper Fatigue Scale (PFS). Secondary outcomes included health-related physical fitness [lumbar strength (back dynamometer), lumbar flexibility (Schöber test), body balance (Flamingo test) and cardiorespiratory fitness (6-minute walking test, 6MWT)], sleep quality (Pittsburgh Sleep Quality Index, PSQI), anxiety and depression (Hospital Anxiety and Depression Scale, HADS), digestive complaints (Gastrointestinal quality of life index, GIQLI), and sexual function (Female sexual function index, FSFI). Outcomes were measured at baseline, post-intervention, and at one year. Statistical (between-group analyses of covariance) and clinical effects were analyzed by intention-to-treat. The study was registered with ClinicalTrials.gov #NCT03979183.

Results

After the intervention and at 1 year, the ‘Physio-EndEA’ group showed significantly improved fatigue compared with the control group, with large size effects (d > 0.80). Post-intervention improvements were also observed in the intervention group for lumbar strength, cardiorespiratory fitness, anxiety, depression, and digestive complaint scores. Improvements in cardiorespiratory fitness, anxiety and digestive complaints were maintained at the 1-year follow-up.

Conclusions

A 9-week supervised multimodal therapeutic exercise program is effective in ameliorating a broad range of endometriosis-related impairments, suggesting that ‘Physio-EndEA’ is a promising strategy for reducing symptom burden in women with endometriosis unresponsive to conventional treatment.

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.