新型1,5-二芳基-3-三氟吡唑抗真菌农药的发现

IF 3.8 1区农林科学 Q1 AGRONOMY

Pest Management Science Pub Date : 2025-05-28 DOI:10.1002/ps.8909

Yihui Ma, Dangwei Yang, Guangyu Qin, Jun Yang, Xianglong Sun, Xiaoyu Gao

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引用次数: 0

摘要

植物病原真菌引起的植物病害继续威胁着全球粮食安全，迫切需要发现具有新型作用模式的抗真菌农用化学品。1,5-二芳基-3-三氟吡唑的基序被发现与潜在的抗真菌作用有关，而HNNK-5就是我们实验室正在开发的具有中等效力的农用化学品。本研究以HNNK-5为母体化合物进行先导物优化，以发现新型杀菌剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Discovery of novel 1,5-diaryl-3-trifluoropyrazoles as antifungal pesticides for crop protection

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Discovery of novel 1,5-diaryl-3-trifluoropyrazoles as antifungal pesticides for crop protection

Plant diseases caused by phytopathogenic fungi continue to threaten global food security, driving the urgent need for discovery of antifungal agrochemicals with novel modes of action. The motif of 1,5-diaryl-3-trifluoropyrazole was found to be associated with potential antifungal effect and HNNK-5 was such an agrochemical being developed in our lab with moderate potency. This study took HNNK-5 as the parent compound for lead optimization to discovery novel fungicides.

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来源期刊

Pest Management Science 农林科学-昆虫学

CiteScore

7.90

自引率

9.80%

发文量

553

审稿时长

4.8 months

期刊介绍： Pest Management Science is the international journal of research and development in crop protection and pest control. Since its launch in 1970, the journal has become the premier forum for papers on the discovery, application, and impact on the environment of products and strategies designed for pest management. Published for SCI by John Wiley & Sons Ltd.